Department of Molecular and Life Science, Hanyang University, Ansan, Republic of Korea.
Institute of Natural Science and Technology, Hanyang University, Ansan, Republic of Korea.
Int J Biol Sci. 2017 Sep 5;13(9):1100-1108. doi: 10.7150/ijbs.21047. eCollection 2017.
Ethanol is well known for its teratogenic effects during fetal development. Maternal alcohol consumption allows the developing fetus to experience the detrimental effects of alcohol exposure. Alcohol-mediated teratogenic effects can vary based on the dosage and the length of exposure. The specific mechanism of action behind this teratogenic effect is still unknown. Previous reports demonstrated that alcohol participates in epigenetic alterations, especially histone modifications during fetal development. Additional research is necessary to understand the correlation between major epigenetic events and alcohol-mediated teratogenesis such as that observed in fetal alcohol spectrum disorder (FASD). Here, we attempted to collect all the available information concerning alcohol-mediated histone modifications during gestational fetal development. We hope that this review will aid researchers to further examine the issues associated with ethanol exposure.
乙醇在胎儿发育过程中具有致畸作用，这是众所周知的。母体饮酒会使发育中的胎儿受到酒精暴露的有害影响。酒精介导的致畸作用可能因剂量和暴露时间的长短而有所不同。这种致畸作用的确切机制尚不清楚。以前的报告表明，酒精参与了表观遗传改变，特别是在胎儿发育过程中的组蛋白修饰。需要进一步的研究来了解主要的表观遗传事件与酒精介导的致畸作用之间的相关性，如胎儿酒精谱系障碍（FASD）中观察到的那样。在这里，我们试图收集所有关于妊娠期胎儿发育过程中酒精介导的组蛋白修饰的可用信息。我们希望本综述将有助于研究人员进一步研究与乙醇暴露相关的问题。
