Baker D A, Salvatore W, Milch P O
Dept. Obstetrics & Gynecology, S.U.N.Y., Stony Brook, NY 11794.
Contraception. 1989 Jan;39(1):119-24. doi: 10.1016/0010-7824(89)90020-6.
Several reports indicate an association between oral contraceptives and increased infection rates. One mechanism that could explain this increased infection rate is a decrease in immune function. A study comparing T cell subsets showed no differences in numbers between oral contraceptive users and controls. In this study, natural killer cell activity was compared in women before and 3 and 6 months after oral contraceptive use. There was a statistically significant decrease in NK cell activity after three months. There was no further decrease by six months and the differences were no longer significant due to greater variability. No infections were reported during the study period. Thus, the observed reduction in NK activity was either physiologically insignificant or the previously reported increase in infections may be the result of non-immunological factors.
多项报告表明口服避孕药与感染率升高之间存在关联。一种可以解释这种感染率升高的机制是免疫功能下降。一项比较T细胞亚群的研究显示，口服避孕药使用者和对照组在数量上没有差异。在这项研究中，对女性在使用口服避孕药前以及使用后3个月和6个月的自然杀伤细胞活性进行了比较。三个月后，自然杀伤细胞活性有统计学意义的下降。到六个月时没有进一步下降，并且由于变异性更大，差异不再显著。在研究期间没有感染报告。因此，观察到的自然杀伤细胞活性降低要么在生理上不显著，要么之前报告的感染增加可能是非免疫因素导致的结果。
