人类宿主-微生物组相互作用的功能基因组学。
Functional Genomics of Host-Microbiome Interactions in Humans.
机构信息
Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA; Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
Department of Medicine, Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, IL, USA.
出版信息
Trends Genet. 2018 Jan;34(1):30-40. doi: 10.1016/j.tig.2017.10.001. Epub 2017 Oct 26.
The human microbiome has been linked to various host phenotypes and has been implicated in many complex human diseases. Recent genome-wide association studies (GWASs) have used microbiome variation as a complex trait and have uncovered human genetic variants that are associated with the microbiome. Here we summarize results from these studies and illustrate potential regulatory mechanisms by which host genetic variation can interact with microbiome composition. We argue that, similar to human GWASs, it is important to use functional genomics techniques to gain a mechanistic understanding of causal host-microbiome interactions and their role in human disease. We highlight experimental, functional, and computational genomics methodologies for the study of the genomic basis of host-microbiome interactions and describe how these approaches can be utilized to explain how human genetic variation can modulate the effects of the microbiome on the host.
人类微生物组与各种宿主表型有关，并与许多复杂的人类疾病有关。最近的全基因组关联研究（GWAS）将微生物组变异作为一种复杂特征，并发现了与微生物组相关的人类遗传变异。在这里，我们总结了这些研究的结果，并说明了宿主遗传变异与微生物组组成相互作用的潜在调节机制。我们认为，与人类 GWAS 类似，使用功能基因组学技术来深入了解宿主-微生物组相互作用的机制及其在人类疾病中的作用非常重要。我们重点介绍了用于研究宿主-微生物组相互作用的基因组基础的实验、功能和计算基因组学方法，并描述了如何利用这些方法来解释人类遗传变异如何调节微生物组对宿主的影响。
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