用于维持生理平衡和愉悦进食的重叠脑回路。
Overlapping Brain Circuits for Homeostatic and Hedonic Feeding.
机构信息
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Cell Metab. 2018 Jan 9;27(1):42-56. doi: 10.1016/j.cmet.2017.09.021. Epub 2017 Nov 5.
Central regulation of food intake is a key mechanism contributing to energy homeostasis. Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's reward circuitry both anatomically and functionally. Manipulation of numerous neural pathways can simultaneously influence food intake and reward. Two key systems underlying these processes-those controlling homeostatic and hedonic feeding-are often treated as independent. Homeostatic feeding is necessary for basic metabolic processes and survival, while hedonic feeding is driven by sensory perception or pleasure. Despite this distinction, their functional and anatomical overlap implies considerable interaction that is often overlooked. Here, we argue that the neurocircuits controlling homeostatic feeding and hedonic feeding are not completely dissociable given the current data and urge researchers to assess behaviors extending beyond food intake in investigations of the neural control of feeding.
摄食的中枢调控是能量平衡的关键机制。许多被认为能够调节摄食行为的神经回路在解剖和功能上与大脑的奖励回路重叠。对许多神经通路的操纵可以同时影响食物摄入和奖励。这两个过程的关键系统——控制生理性摄食和享乐性摄食的系统——通常被视为独立的。生理性摄食是基本代谢过程和生存所必需的，而享乐性摄食则是由感觉感知或愉悦驱动的。尽管有这种区别，但它们的功能和解剖重叠意味着存在着经常被忽视的大量相互作用。在这里，我们认为，考虑到目前的数据，控制生理性摄食和享乐性摄食的神经回路并不是完全可分离的，并敦促研究人员在研究摄食的神经控制时，评估超越食物摄入的行为。
Zotero 插件