Department of Psychology, University of Maryland, College Park, MD, United States.
Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States.
Neurotoxicol Teratol. 2018 Jan-Feb;65:70-77. doi: 10.1016/j.ntt.2017.10.008. Epub 2017 Oct 28.
The objective of the current study was to examine what stage of memory (encoding or retrieval) may be compromised in adolescents with a history of prenatal drug exposure (PDE) and how the effects of PDE on memory ability are substantiated at the neural level. To achieve this goal, we examined memory performance and associated brain activations in adolescents with and without a history of PDE via event-related fMRI during encoding and retrieval. Consistent with previous studies, we found that PDE subjects remembered fewer items than community comparison subjects. However, there were no differences in behavior after adjusting for correct rejections (i.e., d'). Novel extensions of previous work are findings that PDE is associated with changes in brain activation during memory encoding but not during retrieval. These results suggest that less optimal memory performance often observed in adolescents with a history of PDE may result from variations in encoding rather than retrieval processes.
本研究的目的是探讨有产前药物暴露（PDE）史的青少年在记忆的哪个阶段（编码或检索）可能受损，以及 PDE 对记忆能力的影响如何在神经水平上得到证实。为了实现这一目标，我们通过事件相关 fMRI 在编码和检索期间检查了有和没有 PDE 史的青少年的记忆表现和相关的大脑激活。与先前的研究一致，我们发现 PDE 组受试者的记忆量少于社区对照组。然而，在调整正确拒绝（即 d'）后，行为没有差异。与以往工作的新颖扩展是发现 PDE 与记忆编码过程中而不是检索过程中的大脑激活变化有关。这些结果表明，有 PDE 史的青少年中经常观察到的较差的记忆表现可能是由于编码过程而不是检索过程的变化所致。
