Manzoor Hina, Naheed Hamida, Ahmad Khushnaseeb, Iftikhar Shehla, Asif Muhammad, Shuja Jamila, Sultan Neelam, Ali Irfan, Inayatullah Syed, Khan Yasir Hayat
Centre for Nuclear medicine and Radiotherapy (CENAR), Quetta 87300, Pakistan.
Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta 87300, Pakistan.
Biomed Rep. 2017 Nov;7(5):487-491. doi: 10.3892/br.2017.993. Epub 2017 Sep 28.
Gynaecological malignancies contribute significantly to cancer burden and have a higher rate of mortality and morbidity. The aim of this retrospective study was to determine the pattern of gynaecological malignancies identified between January, 2000 and December, 2011, at the Centre for Nuclear Medicine and Radiotherapy (CENAR). At CENAR 5,072 female patients were registered with different malignancies, of which 632 cases were gynaecological malignancies. Ovarian cancer (47%) was the most common gynaecological malignancy, followed by cervical cancer (29%), uterine cancer (14%), vulvar and vaginal cancer (6%), and gestational trophoblastic neoplasm (4%). Of the ovarian cancer cases, 72.5% had epithelial while 26.5% had non-epithelial cancer. Squamous cell carcinoma was 75.9% in cervix and 87.8% in vulva and vagina while endometrial carcinoma (75.9%) was more frequent in uterus. For gestational trophoblastic neoplasm, 69.2% of patients had choriocarcinoma. Ovarian cancer was the most common type for the age range of 50-59 years. In the case of cervical and gestational trophoblastic neoplasm the majority of patients presented at the ages of 40-49 and 30-39 years while uterus, vulvar and vaginal tumor presented in the elderly (>60 years). Thus, ovarian cancer is the leading gynecological malignancy in Pakistan.
妇科恶性肿瘤在癌症负担中占比显著，且死亡率和发病率较高。本回顾性研究的目的是确定2000年1月至2011年12月期间在核医学与放射治疗中心（CENAR）确诊的妇科恶性肿瘤模式。在CENAR，5072名女性患者被登记患有不同的恶性肿瘤，其中632例为妇科恶性肿瘤。卵巢癌（47%）是最常见的妇科恶性肿瘤，其次是宫颈癌（29%）、子宫癌（14%）、外阴和阴道癌（6%）以及妊娠滋养细胞肿瘤（4%）。在卵巢癌病例中，72.5%为上皮性癌，26.5%为非上皮性癌。宫颈癌中鳞状细胞癌占75.9%，外阴和阴道癌中占87.8%，而子宫内膜癌（75.9%）在子宫中更为常见。对于妊娠滋养细胞肿瘤，69.2%的患者患有绒毛膜癌。卵巢癌是50 - 59岁年龄组中最常见的类型。在宫颈癌和妊娠滋养细胞肿瘤病例中，大多数患者年龄在40 - 49岁和30 - 39岁，而子宫、外阴和阴道肿瘤多见于老年患者（>60岁）。因此，卵巢癌是巴基斯坦主要的妇科恶性肿瘤。
