da Silva Pone Marcos Vinicius, Moura Pone Sheila, Araujo Zin Andrea, Barros Mendes Pedro Henrique, Senra Aibe Mitsue, Barroso de Aguiar Elisa, de Oliveira Gomes da Silva Tallita
Pediatric Infectious Diseases Unit, National Institute of Women, Children and Adolescents Health Fernandes Figueira (IFF)/Oswaldo Cruz Foundation (FIOCRUZ), Av. Rui Barbosa 716, Rio de Janeiro, 22250-020, Brazil.
Clinical Research Unit, National Institute of Women, Children and Adolescents Health Fernandes Figueira (IFF)/Oswaldo Cruz Foundation (FIOCRUZ), Av. Rui Barbosa 716, Rio de Janeiro, 22250-020, Brazil.
Childs Nerv Syst. 2018 Jan;34(1):63-71. doi: 10.1007/s00381-017-3635-3. Epub 2017 Nov 6.
The purpose of this review is to comprehensively review Congenital Zika Syndrome in regard to their epidemiology and clinical manifestations.
This subject review of congenital Zika syndrome was composed after conducting a thorough review of the available literature on this topic using PubMed and other primary sources.
The first epidemic of Zika virus infection in Brazil was followed by an unexpected sharp increase in the incidence of infants born with microcephaly and the description of a new disease, the congenital Zika syndrome. This review focuses on the epidemiological and clinical aspects of Zika infection in children. We conducted a brief historical account of the virus description in 1947, the rare cases of Zika infection occurring up to 2007, and the first epidemics in the Pacific between 2007 and 2014. We also discussed the isolation of the virus in Brazil in 2015 and its spread in the Americas, the microcephaly outbreak in Brazil and its association with Zika virus, and the current epidemiological panorama. We address the known clinical spectrum of Zika virus infection in the pediatric population, including manifestations of acute infection and congenital Zika syndrome, with emphasis on cranial, ophthalmic, and orthopedic abnormalities.
While much has been learned about congenital Zika syndrome, the full spectrum of this infection is not yet known. This review is based on current, limited data about Zika vírus infection. As more information becomes available, we will have a more accurate picture of this new disease.
本综述旨在全面回顾先天性寨卡综合征的流行病学和临床表现。
在使用PubMed和其他主要来源对该主题的现有文献进行全面回顾之后，撰写了本关于先天性寨卡综合征的主题综述。
巴西首次出现寨卡病毒感染疫情后，出生时患有小头畸形的婴儿发病率意外急剧上升，并出现了一种新疾病——先天性寨卡综合征。本综述重点关注儿童寨卡病毒感染的流行病学和临床方面。我们简要介绍了1947年对该病毒的描述、截至2007年发生的罕见寨卡病毒感染病例，以及2007年至2014年期间在太平洋地区的首次疫情。我们还讨论了2015年该病毒在巴西的分离及其在美洲的传播、巴西的小头畸形疫情及其与寨卡病毒的关联，以及当前的流行病学概况。我们阐述了儿科人群中寨卡病毒感染已知的临床谱，包括急性感染和先天性寨卡综合征的表现，重点是颅骨、眼科和骨科异常。
虽然关于先天性寨卡综合征已经了解很多，但这种感染的全貌尚不清楚。本综述基于目前关于寨卡病毒感染的有限数据。随着更多信息的出现，我们将对这种新疾病有更准确的认识。
