Benzekri R, Belfort R, Ventura C V, de Paula Freitas B, Maia M, Leite M, Labetoulle M, Rousseau A
Service d'ophtalmologie, hôpital de Bicêtre, Assistance publique-Hôpitaux de Paris, DHU vision et handicap, université Paris-Sud, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France.
Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of São Paulo and Vision Institute, São Paulo, Brésil.
J Fr Ophtalmol. 2017 Feb;40(2):138-145. doi: 10.1016/j.jfo.2017.01.002. Epub 2017 Feb 9.
Zika virus (ZIKV) disease outbreak, which was declared by the end of 2015 in Brazil, has become the largest one to date. Being reported in the Americas and in certain islands of the Pacific, it has the potential to spread worldwide. Although ZIKV infections are mostly self-limiting and/or asymptomatic in the healthy adult, they are responsible for devastating congenital neurologic malformations ZIKV (mainly microcephaly) when contracted during the first months of pregnancy. Ocular manifestations during the acute adult infection include conjunctivitis and more rarely ocular inflammation. Congenital infection is associated with chorioretinal atrophy pigment mottling of the retina retinal vasculature abnormalities and optic nerve atrophy. Therefore, complete ophthalmological evaluation is recommended for suspected congenital infections.
寨卡病毒（ZIKV）疾病疫情于2015年底在巴西被宣布爆发，成为迄今为止规模最大的一次疫情。该疫情已在美洲和太平洋的某些岛屿被报道，有在全球传播的可能性。虽然寨卡病毒感染在健康成年人中大多是自限性的和/或无症状的，但在怀孕头几个月感染时，会导致严重的先天性神经畸形（主要是小头畸形）。急性成人感染期间的眼部表现包括结膜炎，较少见的还有眼部炎症。先天性感染与脉络膜视网膜萎缩、视网膜色素斑驳、视网膜血管异常和视神经萎缩有关。因此，对于疑似先天性感染建议进行全面的眼科评估。
