马里广泛耐药结核病：一例报告
Extensively drug resistant tuberculosis in Mali: a case report.
作者信息
Diarra Bassirou, Toloba Yacouba, Konate Bakary, Sanogo Moumine, Togo Antieme Combo Georges, Camara Fatimata, Berthe Gaoussou, Soumaré Dianguina, Baya Bocar, Goita Drissa, Sarro Yeya Dit Sadio, Maiga Mamoudou, Belson Michael, Orsega Susan, Dao Sounkalo, Murphy Robert L, Siddiqui Sophia, de Jong Bouke C, Doumbia Seydou, Diallo Souleymane
机构信息
University Clinical Research Center (UCRC)-SEREFO-Laboratory, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
出版信息
BMC Res Notes. 2017 Nov 6;10(1):561. doi: 10.1186/s13104-017-2890-4.
BACKGROUND
Drug resistant tuberculosis presents a major public health challenge.
CASE PRESENTATION
We present here the first two patients diagnosed with extensively drug resistant tuberculosis in Bamako, Mali. Genotypic findings suggest possible nosocomial transmission from the first patient to the second one, resulting in superinfection of the second patient. After being diagnosed with extensively drug resistant tuberculosis in August 2016, the patients only started receiving appropriate treatment 10 months later.
CONCLUSION
The identification of these patients highlights the need for improved diagnostic and treatment algorithms for better surveillance and management of drug resistance in Mali. In the interest of these as well as future patients suffering from resistant tuberculosis, all steps recommended for programmatic management of drug resistant tuberculosis must be urgently prioritized in order to strengthen the multidrug resistant tuberculosis program.
背景
耐药结核病是一项重大的公共卫生挑战。
病例报告
我们在此介绍马里巴马科首批两名被诊断为广泛耐药结核病的患者。基因分型结果表明可能存在从首例患者到第二例患者的医院内传播，导致第二例患者发生重叠感染。这两名患者在2016年8月被诊断为广泛耐药结核病后，10个月后才开始接受适当治疗。
结论
这些患者的确诊凸显了在马里改进诊断和治疗算法以更好地监测和管理耐药性的必要性。为了这些患者以及未来患有耐药结核病的患者，必须紧急优先处理耐药结核病规划管理所推荐的所有步骤，以加强耐多药结核病规划。
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