Department of Global Health, University of Washington, Seattle, Washington, USA.
Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
AIDS. 2018 Jan 14;32(2):267-270. doi: 10.1097/QAD.0000000000001680.
: Polymorphisms in the Toll-like receptor 9 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed infants by 1635 genotype. Having one or more copies of the 1635A allele was associated with increased CMV acquisition in HIV-infected infants (42 vs. 11%, P = 0.03) and increased risk of EBV acquisition in HIV-exposed uninfected infants (hazard ratio = 4.2, P = 0.02) compared with 1635GG. In addition, 1635A was associated with 0.4 log10 copies/ml lower median EBV levels in HIV-infected infants (P = 0.03). These data suggest a potentially important role for this locus in primary herpesvirus infection.
Toll 样受体 9 1635 位点的多态性与 HIV-1 的获得和进展有关。通过 1635 基因型比较肯尼亚 HIV 暴露婴儿的巨细胞病毒 (CMV) 和 EBV 获得情况。与 1635GG 相比，携带一个或多个 1635A 等位基因的个体中 HIV 感染婴儿的 CMV 获得增加（42% vs. 11%，P = 0.03），HIV 暴露未感染婴儿的 EBV 获得风险增加（危险比 = 4.2，P = 0.02）。此外，与 1635GG 相比，1635A 与 HIV 感染婴儿中 EBV 中位数水平降低 0.4log10 拷贝/ml 相关（P = 0.03）。这些数据表明该基因座在原发性疱疹病毒感染中具有潜在的重要作用。
