Berthelsen Jørgen G, Skakkebaek Niels E
Laboratory of Reproductive Biology, University Department of Obstetrics and Gynaecology YA, Rigshospitalet, CopenhagenDepartment of Gynaecology and Obstetrics, Herlev Hospital, University of Copenhagen, Copenhagen.
Int J Androl. 1981 Mar;4 Suppl s4:172-183. doi: 10.1111/j.1365-2605.1981.tb00672.x.
Quantitative histologial studies on 4 testes removed because of carcinoma-in-situ (CIS) were performed in order to determine the distribution of CIS within the testis and to estimate the likelihood of diagnosing testicular CIS by biopsy. The CIS changes were distributed in all parts of the testes but were less frequent in the parts adjacent to the epididymis. In the 4 testes examined 1.4 to 599 of the entire testicular volume contained seminiferous tubules with CIS. In parts of the testes where more than approximately 10% of the testicular volume consisted of tubules with CIS all simulated biopsies measuring 3 mm contained the lesion. The same was true for simulated biopsies measuring 1.5 mm when more then approximately 30% of the testicular volume consisted of tubules with CIS. If the distribution of CIS generally is similar to that found in the 4 analysed testes there seems to be a high probability of detecting the disease by one or two testicular biopsies.
对4个因原位癌（CIS）而切除的睾丸进行了定量组织学研究，以确定CIS在睾丸内的分布，并评估通过活检诊断睾丸CIS的可能性。CIS改变分布于睾丸的所有部位，但在附睾附近的部位较少见。在检查的4个睾丸中，整个睾丸体积的1.4%至599%包含有CIS的生精小管。在睾丸中，当超过约10%的睾丸体积由有CIS的小管组成时，所有3毫米的模拟活检都包含该病变。当超过约30%的睾丸体积由有CIS的小管组成时，1.5毫米的模拟活检也是如此。如果CIS的分布总体上与在4个分析的睾丸中发现的相似，那么通过一两次睾丸活检检测到该病的可能性似乎很高。
