Skakkebaek Niels E, Berthelsen Jørgen G, Visfeldt Jakob
Laboratory of Reproductive Biology, University Department of Obstetrics and Gynaecology YA, Rigshospitalet, CopenhagenUniversity Department of Paediatrics G, Rigshospitalet, CopenhagenUniversity Department of Gynaecology and Obstetrics, Herlev Hospital, CopenhagenUniversity Department of Pathology, Rigshospitalet, Copenhagen.
Int J Androl. 1981 Mar;4 Suppl s4:153-160. doi: 10.1111/j.1365-2605.1981.tb00668.x.
Carcinoma-in-situ germ cells were demonstrated in testicular biopsies from 9 of 826 patients (1.1%) from a selected group of Danish infertile men. A similar observation was noted in testicular biopsies from 9 Swiss patients (representing 0.55% of the total number of infertile patients biopsied in that study). Such changes were also seen in 8 testicular biopsies from the contralateral testis of 180 patients (4.4%) with carcinoma of the teitis. Moreover, carcinoma-in-situ has beer, found in maldecended testes and in gonads of patients with the testicular feminization syndrome although the incidence of carcinoma-in-situ in these two latter groups is unknown. The malignant potential of carcinoma-in-situ of the testis in infertile men has been clearly demonstrated, whereas its clinical significance in other groups of patients remains to be determined.
在一组特定的丹麦不育男性中，826例患者的睾丸活检中有9例（1.1%）发现原位癌生殖细胞。在9例瑞士患者的睾丸活检中也观察到类似情况（占该研究中活检的不育患者总数的0.55%）。在180例睾丸癌患者对侧睾丸的8例活检中也发现了此类变化（4.4%）。此外，在隐睾以及睾丸女性化综合征患者的性腺中也发现了原位癌，尽管后两组中原位癌的发病率尚不清楚。不育男性睾丸原位癌的恶性潜能已得到明确证实，而其在其他患者群体中的临床意义仍有待确定。
