Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians Universität München, 80337 Munich, Germany.
Department of Obstetrics and Gynecology, Klinik Hallerwiese, 90419 Nürnberg, Germany.
Int J Mol Sci. 2017 Nov 6;18(11):2340. doi: 10.3390/ijms18112340.
Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.
维生素 D 除了在骨骼代谢中的经典作用外，还在胎儿-母体单位的多个途径中发挥独特作用。1,25-二羟维生素 D3（calcitriol）是核维生素 D 受体（VDR）的主要活性配体。维生素 D 受体（VDR）在不同的胎盘部位表达，并在生理妊娠中发挥多种功能。它调节蜕膜化和着床，影响激素分泌和胎盘免疫调节。本综述强调了维生素 D 受体在生理和异常妊娠中的作用，如子痫前期、胎儿生长受限、妊娠期糖尿病和早产。我们讨论了关于这些妊娠疾病中常见 VDR 多态性的现有文献。
