Kumar Raj, Tiku A B
Cancer and Radiation Therapeutics Laboratory, School of Life Sciences, JNU, New Delhi 110067, India.
Cancer and Radiation Therapeutics Laboratory, School of Life Sciences, JNU, New Delhi 110067, India.
Chem Biol Interact. 2018 Jan 5;279:1-9. doi: 10.1016/j.cbi.2017.11.001. Epub 2017 Nov 4.
The present study was designed to understand the anticancer property and molecular mechanisms associated with chemo preventive effects of galangin. The anticancer effect was evaluated in vitro using human cervical cancer cell line (HeLa). Galangin was found to be effective in inducing cell death and inhibiting proliferation & migration significantly. The inhibitory effect of galangin could be correlated with the increase in ROS production & induction of apoptosis. Besides this the activity of glyoxalase-1, an enzyme important for the detoxification of cytotoxic metabolite methy glyoxal and Nrf-2 (a trascription factor), involved in redox signalling were found to be decreased. We concluded that galangin exerts its chemo preventive effect via redox signalling by inhibiting glyoxalase-1 & increasing oxidative & carbonyl stress.
本研究旨在了解高良姜素的抗癌特性及其与化学预防作用相关的分子机制。使用人宫颈癌细胞系（HeLa）在体外评估了高良姜素的抗癌效果。发现高良姜素在诱导细胞死亡以及显著抑制增殖和迁移方面有效。高良姜素的抑制作用可能与活性氧生成增加和细胞凋亡诱导有关。除此之外，还发现乙二醛酶-1（一种对细胞毒性代谢物甲基乙二醛解毒很重要的酶）和参与氧化还原信号传导的转录因子Nrf-2的活性降低。我们得出结论，高良姜素通过抑制乙二醛酶-1并增加氧化应激和羰基应激，经由氧化还原信号传导发挥其化学预防作用。
