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微波辅助简便合成聚（鲁米诺 - 苯二胺）共聚物及其在生物医学成像中的潜在应用。

Microwave-assisted facile synthesis of poly(luminol--phenylenediamine) copolymers and their potential application in biomedical imaging.

作者信息

Riaz Ufana, Jadoun Sapana, Kumar Prabhat, Kumar Raj, Yadav Nitin

机构信息

Materials Research Laboratory, Department of Chemistry, Jamia Millia Islamia New Delhi-110025 India

Advanced Instrumentation Research Facility, Jawaharlal Nehru University New Delhi-110067 India.

出版信息

RSC Adv. 2018 Nov 6;8(65):37165-37175. doi: 10.1039/c8ra08373h. eCollection 2018 Nov 1.

DOI:10.1039/c8ra08373h
PMID:35557797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9089407/
Abstract

Conjugated copolymers have attracted much attention because of their outstanding photo-physical properties. The present work reports for the first time, microwave-assisted copolymerization of -phenylenediamine with luminol using different weight ratios of the two monomers. The composition of the copolymers was confirmed by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance spectroscopy (H-NMR) while monomer reactivity ratios were determined using the Fineman-Ross method. Ultraviolet-visible spectroscopy revealed the variation in polaronic states upon copolymerization while X-ray diffraction (XRD) and transmission electron microscopy (TEM) analyses showed the morphology of the copolymers to be intermediate between that of the homopolymers. Confocal analysis and fluorescence studies revealed that the copolymers showed composition based blue as well as red emission which could be utilized for imaging of cancer cells.

摘要

共轭共聚物因其出色的光物理性质而备受关注。本工作首次报道了对苯二胺与鲁米诺在不同重量比的两种单体条件下的微波辅助共聚反应。通过傅里叶变换红外光谱（FTIR）和核磁共振光谱（H-NMR）确定了共聚物的组成，同时使用芬曼-罗斯方法测定了单体反应比。紫外-可见光谱揭示了共聚时极化子态的变化，而X射线衍射（XRD）和透射电子显微镜（TEM）分析表明共聚物的形态介于均聚物之间。共聚焦分析和荧光研究表明，共聚物呈现基于组成的蓝色以及红色发射，可用于癌细胞成像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/0e04229fa794/c8ra08373h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/4aacdcaca6af/c8ra08373h-s1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/7a5a7accd507/c8ra08373h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/521dab037e25/c8ra08373h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/de2e40299edc/c8ra08373h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/694f957367cc/c8ra08373h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/9514b9c40487/c8ra08373h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/5d004c43f96b/c8ra08373h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/0e04229fa794/c8ra08373h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/4aacdcaca6af/c8ra08373h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/0af17155c065/c8ra08373h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/7a5a7accd507/c8ra08373h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/521dab037e25/c8ra08373h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/de2e40299edc/c8ra08373h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/694f957367cc/c8ra08373h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/9514b9c40487/c8ra08373h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/5d004c43f96b/c8ra08373h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cd/9089407/0e04229fa794/c8ra08373h-f8.jpg

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