Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan.
Eur Arch Psychiatry Clin Neurosci. 2018 Dec;268(8):865-870. doi: 10.1007/s00406-017-0848-0. Epub 2017 Nov 8.
The transcription factor Keap1-Nrf2 signaling plays a key role in the oxidative stress which is involved in psychiatric disorders. In the learned helplessness (LH) paradigm, protein levels of Keap1 and Nrf2 in the prefrontal cortex and dentate gyrus of hippocampus from LH (susceptible) rats were lower than control and non-LH (resilience) rats. Furthermore, protein expressions of Keap1 and Nrf2 in the parietal cortex from major depressive disorder, schizophrenia, and bipolar disorder were lower than controls. These results suggest that Keap1-Nrf2 signaling might contribute to stress resilience which plays a key role in the pathophysiology of psychiatric disorders.
转录因子 Keap1-Nrf2 信号通路在氧化应激中起关键作用，而氧化应激与精神疾病有关。在习得性无助（LH）模型中，LH（易感）大鼠前额叶皮层和海马齿状回中的 Keap1 和 Nrf2 蛋白水平低于对照组和非 LH（适应）大鼠。此外，重度抑郁症、精神分裂症和双相情感障碍患者顶叶皮层中的 Keap1 和 Nrf2 蛋白表达也低于对照组。这些结果表明，Keap1-Nrf2 信号通路可能有助于应激适应，而应激适应在精神疾病的病理生理学中起关键作用。
