Yang Bangkun, Yang Chun, Ren Qian, Zhang Ji-Chun, Chen Qian-Xue, Shirayama Yukihiko, Hashimoto Kenji
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
Eur Arch Psychiatry Clin Neurosci. 2016 Dec;266(8):765-769. doi: 10.1007/s00406-016-0693-6. Epub 2016 Apr 19.
Using learned helplessness (LH) model of depression, we measured protein expression of brain-derived neurotrophic factor (BDNF) pro-peptide, BDNF precursors (proBDNF and preproBDNF) in the brain regions of LH (susceptible) and non-LH rats (resilience). Expression of preproBDNF, proBDNF and BDNF pro-peptide in the medial prefrontal cortex of LH rats, but not non-LH rats, was significantly higher than control rats, although expression of these proteins in the nucleus accumbens of LH rats was significantly lower than control rats. This study suggests that regional differences in conversion of BDNF precursors into BDNF and BDNF pro-peptide by proteolytic cleavage may contribute to stress resilience.
利用抑郁症的习得性无助（LH）模型，我们测量了LH（易感性）大鼠和非LH大鼠（恢复力）脑区中脑源性神经营养因子（BDNF）前体肽、BDNF前体（proBDNF和前proBDNF）的蛋白表达。尽管LH大鼠伏隔核中这些蛋白的表达显著低于对照大鼠，但LH大鼠内侧前额叶皮质中前proBDNF、proBDNF和BDNF前体肽的表达显著高于对照大鼠，而非LH大鼠则不然。本研究表明，通过蛋白水解切割将BDNF前体转化为BDNF和BDNF前体肽的区域差异可能有助于应激恢复力。
