Yadrick M K, Kenney M A, Winterfeldt E A
Department of Food, Nutrition, Oklahoma State University, Stillwater.
Am J Clin Nutr. 1989 Jan;49(1):145-50. doi: 10.1093/ajcn/49.1.145.
Response of iron, copper, and zinc status to supplementation with Zn or a combination of Zn and Fe was assessed in adult females in a 10-wk study. Group Z received 50 mg Zn/d as Zn gluconate; group F-Z received 50 mg Fe as ferrous sulfate monohydrate in addition to the Zn. For Group Z, serum ferritin, hematocrit, and erythrocyte Cu,Zn-superoxide dismutase (ESOD) were significantly lower (p less than 0.05) after 10 wk supplementation compared with pretreatment levels. Serum Zn increased (p less than 0.01) but no change occurred in serum ceruloplasmin, hemoglobin, or salivary sediment Zn with treatment. For Group F-Z ESOD decreased with treatment as did salivary sediment Zn (p less than 0.05). Serum ferritin and serum Zn increased significantly, but hemoglobin, hematocrit, and ceruloplasmin were not affected by this treatment. Supplementation with Zn poses a risk to Fe and Cu status. Inclusion of Fe with Zn ameliorates the effect on Fe but not on Cu status.
在一项为期10周的研究中，评估了成年女性补充锌或锌与铁的组合后铁、铜和锌状态的反应。Z组每天服用50毫克葡萄糖酸锌；F-Z组除了锌之外，还服用50毫克一水硫酸亚铁。对于Z组，补充10周后，血清铁蛋白、血细胞比容和红细胞铜锌超氧化物歧化酶（ESOD）与治疗前水平相比显著降低（p<0.05）。血清锌增加（p<0.01），但治疗后血清铜蓝蛋白、血红蛋白或唾液沉淀物锌没有变化。对于F-Z组，ESOD和唾液沉淀物锌随治疗而降低（p<0.05）。血清铁蛋白和血清锌显著增加，但血红蛋白、血细胞比容和铜蓝蛋白不受该治疗影响。补充锌对铁和铜状态有风险。锌与铁一起补充可改善对铁的影响，但对铜状态无改善作用。
