Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, United States.
Curr Opin Genet Dev. 2017 Dec;47:121-127. doi: 10.1016/j.gde.2017.09.004. Epub 2017 Nov 8.
The binding of transcription regulators to cis-regulatory sequences is a key step through which all cells regulate expression of their genes. Due to gains and losses of cis-regulatory sequences and changes in the transcription regulators themselves, the binding connections between regulators and their target genes rapidly change over evolutionary time and constitute a major source of biological novelty. This review covers recent work, carried out in a wide range of species, that addresses the overall extent of these evolutionary changes, their consequences, and some of the molecular mechanisms that lie behind them.
转录调控因子与顺式调控序列的结合是所有细胞调控基因表达的关键步骤。由于顺式调控序列的获得和丧失以及转录调控因子本身的变化，调控因子与其靶基因之间的结合连接在进化过程中迅速变化，构成了生物新颖性的主要来源。这篇综述涵盖了最近在广泛的物种中进行的工作，这些工作解决了这些进化变化的总体程度、它们的后果以及它们背后的一些分子机制。
