基础S-亚硝基化是组织稳态的守护者。
Basal S-Nitrosylation Is the Guardian of Tissue Homeostasis.
作者信息
Furuta Saori
机构信息
Department of Cancer Biology, University of Toledo Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA.
出版信息
Trends Cancer. 2017 Nov;3(11):744-748. doi: 10.1016/j.trecan.2017.09.003. Epub 2017 Oct 4.
PMID:29120749
Abstract
Recent studies have uncovered that nitric oxide (NO) signaling is largely conducted by S-nitrosylation, involving >3000 proteins. The nitrosyl group could then travel further by transnitrosylation or be secreted, enabling regulation of the whole tissue. A subset of proteins are constitutively S-nitrosylated, playing roles in the regulation of tissue homeostasis.
摘要
最近的研究发现，一氧化氮（NO）信号传导主要通过S-亚硝基化进行，涉及超过3000种蛋白质。亚硝基基团随后可通过转亚硝基化进一步传递或被分泌，从而实现对整个组织的调节。一部分蛋白质组成性地发生S-亚硝基化，在组织稳态调节中发挥作用。
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