精液中的人乳头瘤病毒与男性不育风险：一项系统评价和荟萃分析。

Human papillomavirus in semen and the risk for male infertility: a systematic review and meta-analysis.

作者信息

Lyu Zhangyan, Feng Xiaoshuang, Li Ni, Zhao Wei, Wei Luopei, Chen Yuheng, Yang Wenjing, Ma Hongxia, Yao Bing, Zhang Kai, Hu Zhibin, Shen Hongbing, Hang Dong, Dai Min

机构信息

Program Office for Cancer Screening in Urban China, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 Panjiayuannanli, Chaoyang District, Beijing, 100021, China.

Reproductive Medical Center, Jinling Hospital, Nanjing, 210029, China.

出版信息

BMC Infect Dis. 2017 Nov 9;17(1):714. doi: 10.1186/s12879-017-2812-z.

DOI:10.1186/s12879-017-2812-z

PMID:29121862

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5679371/

Abstract

BACKGROUND

Human papillomavirus (HPV) is one of the most prevalent sexually transmitted viruses. Despite the increasing evidence of HPV prevalence in semen, the worldwide distribution of HPV types in semen and risk for male infertility remain inconclusive.

METHODS

Four electronic databases were searched for English language studies conducted between January 1990 and December 2016 that reported HPV DNA prevalence in semen. Based on the PRISMA guidelines, HPV prevalence was estimated among general population and fertility clinic attendees, respectively, and heterogeneity testing was performed using Cochran's Q and I statistics. The association between HPV positivity and male infertility was evaluated by a meta-analysis of case-control studies.

RESULTS

A total of 31 eligible studies comprising 5194 males were included. The overall prevalence of HPV DNA in semen was 11.4% (95% CI = 7.8-15.0%) in general population (n = 2122) and 20.4% (95% CI = 16.2-24.6%) in fertility clinic attendees (n = 3072). High-risk type prevalence was 10.0% (95% CI = 5.9-14.0%) and 15.5% (95% CI = 11.4-19.7%), respectively. HPV16 was the most common type, with a prevalence of 4.8% (95% CI = 1.7-7.8%) in general population and 6.0% (95% CI = 3.8-8.2%) in fertility clinic attendees. A significantly increased risk of infertility was found for males with HPV positivity in semen (OR = 2.93, 95% CI = 2.03-4.24).

CONCLUSIONS

Seminal HPV infection is common worldwide, which may contribute to the risk of male infertility.

摘要

背景

人乳头瘤病毒（HPV）是最常见的性传播病毒之一。尽管有越来越多的证据表明精液中HPV感染率很高，但全球范围内精液中HPV类型的分布以及男性不育的风险仍无定论。

方法

检索了四个电子数据库，查找1990年1月至2016年12月期间进行的报告精液中HPV DNA感染率的英文研究。根据PRISMA指南，分别估计了普通人群和生育诊所就诊者中的HPV感染率，并使用Cochran's Q和I²统计量进行异质性检验。通过病例对照研究的荟萃分析评估了HPV阳性与男性不育之间的关联。

结果

共纳入31项符合条件的研究，涉及5194名男性。普通人群（n = 2122）精液中HPV DNA的总体感染率为11.4%（95%CI = 7.8 - 15.0%），生育诊所就诊者（n = 3072）中为20.4%（95%CI = 16.2 - 24.6%）。高危型感染率分别为10.0%（95%CI = 5.9 - 14.0%）和15.5%（95%CI = 11.4 - 19.7%）。HPV16是最常见的类型，普通人群中的感染率为4.8%（95%CI = 1.7 - 7.8%），生育诊所就诊者中为6.0%（95%CI = 3.8 - 8.2%）。精液中HPV阳性的男性不育风险显著增加（OR = 2.93，95%CI = 2.03 - 4.24）。