洗必泰在非创伤性修复治疗中对残留致龋菌的抑制作用：消毒还是掺入。

Inhibition of Residual Cariogenic Bacteria in Atraumatic Restorative Treatment by Chlorhexidine: Disinfection or Incorporation.

作者信息

Joshi Jooie S, Roshan Noor M, Sakeenabi Basha, Poornima P, Nagaveni N B, Subbareddy V V

机构信息

Pedodontics, College of Dental Sciences, Davangere, Karnataka, India.

Preventive Dental Sciences Department, Pediatric Dentistry Division, Faculty of Dentistry, Taif University, Taif, Saudi Arabia.

出版信息

Pediatr Dent. 2017 Jul 15;39(4):308-312.

PMID:29122072

Abstract

PURPOSE

The purpose of this study was to compare the efficacy of chlorhexidine (CHX) cavity disinfection and of CHX containing glass ionomer cement (GIC) in inhibiting residual cariogenic bacteria.

METHODS

Ninety, five- to nine-year-olds were randomly allocated to three groups: Group 1-CHX containing GIC; Group 2-CHX cavity disinfection; and Group 3-conventional GIC. Total viable count (TVC), Streptococcus mutans (SM), and Lactobacillus (LB) were analyzed pre-, post-, and three months after atraumatic restorative treatment (ART). The results were statistically analyzed by one-way analysis of variance.

RESULTS

At three months microbial evaluation, Group 1 showed 65 percent reduction of both TVC and LB and 67 percent of SM. Group two showed 64 percent, 58 percent, and 56 percent reduction of TVC, LB, and SM respectively. Group 3 exhibited 41 percent, 42 percent, and 46 percent reduction in mean TVC, LB, and SM counts respectively. Residual microbial counts for Group 3 were 0.41, 0.61, and 0.53 (105 colony forming units) for TVC, LB, and SM, respectively, which was significantly higher (P<0.01) compared to the respective microbial counts in Groups 1 and 2.

CONCLUSION

Both chlorhexidine disinfection and incorporation showed superior efficacy in inhibiting residual microbes compared to conventional ART.

摘要

目的

本研究旨在比较氯己定（CHX）窝洞消毒和含氯己定的玻璃离子水门汀（GIC）在抑制残余致龋菌方面的疗效。

方法

90名5至9岁儿童被随机分为三组：第1组——含CHX的GIC；第2组——CHX窝洞消毒；第3组——传统GIC。在非创伤性修复治疗（ART）前、后及三个月时分析总活菌数（TVC）、变形链球菌（SM）和乳酸杆菌（LB）。结果采用单因素方差分析进行统计学分析。

结果

在三个月的微生物评估中，第1组TVC和LB均减少65%，SM减少67%。第2组TVC、LB和SM分别减少64%、58%和56%。第3组TVC、LB和SM平均计数分别减少41%、42%和46%。第3组TVC、LB和SM的残余微生物计数分别为0.41、0.61和0.53（105个菌落形成单位），与第1组和第2组各自的微生物计数相比显著更高（P<0.01）。