Postgraduate Program in Dentistry, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Division of Preventive and Community Dentistry, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Eur Arch Paediatr Dent. 2022 Jun;23(3):365-379. doi: 10.1007/s40368-022-00699-6. Epub 2022 Mar 14.
To evaluate the influence of the addition of chlorhexidine on the antimicrobial effect and on the survival of restorations performed with glass ionomer cement.
Nine databases were used to search for randomized clinical trials that compared the survival rate and the antimicrobial effect of glass ionomer cement (GIC) restorations with and without the incorporation of chlorhexidine (CHX), without restrictions on year or language. Cochrane Collaboration's Risk of Bias 2 was used to assess the risk of bias. The GRADE approach was used to assess the certainty of evidence.
From 593 studies found, seven met the inclusion criteria. The concentration of CHX varied between 0.5 and 2%. In general, the addition of CHX to GIC promoted reductions in Streptococcus mutans and Lactobacillus acidophilus burdens when compared to those without CHX. No study showed a difference in the survival of restorations between GIC with CHX and conventional GIC. Individual risk of bias varied from low to high and the certainty of evidence was classified as very low.
Based on a very low level of certainty, the evidence suggests that the incorporation of CHX in GIC might improve the antimicrobial effects for a short time, in addition to having little influence on the survival of the restoration.
评估在玻璃离子水门汀中添加洗必泰对其抗菌效果和修复体存活率的影响。
使用 9 个数据库检索了比较添加和不添加洗必泰（CHX）的玻璃离子水门汀（GIC）修复体的存活率和抗菌效果的随机临床试验，不限制年份或语言。使用 Cochrane 协作风险偏倚评估 2 来评估偏倚风险。使用 GRADE 方法评估证据的确定性。
从 593 项研究中，有 7 项符合纳入标准。CHX 的浓度在 0.5%至 2%之间变化。一般来说，与不含 CHX 的 GIC 相比，添加 CHX 可降低变形链球菌和嗜酸乳杆菌的负担。没有研究显示添加 CHX 的 GIC 和传统 GIC 之间修复体存活率存在差异。个体偏倚风险从低到高不等，证据确定性被归类为极低。
基于极低的确定性证据表明，在 GIC 中添加 CHX 可能在短期内提高抗菌效果，同时对修复体的存活率影响不大。
