Medical Center - University of Freiburg, Center for Dental Medicine, Department of Prosthetic Dentistry, Faculty of Medicine - University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany; Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin (CBF), CC 3 Dental and Craniofacial Sciences, Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Aßmannshauser Straße 4-6, 14197 Berlin, Germany.
Medical Center - University of Freiburg, Center for Dental Medicine, Department of Prosthetic Dentistry, Faculty of Medicine - University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.
Dent Mater. 2018 Feb;34(2):171-182. doi: 10.1016/j.dental.2017.10.008. Epub 2017 Nov 6.
To determine the osseointegration rate of zirconium dioxide (ZrO) dental implants in preclinical investigations.
Data on the osseointegration rate was extracted considering the bone to implant contact (BIC), removal torque analysis (RTQ) and push-in tests. Meta analyses were conducted using multilevel multivariable mixed-effects linear regression models. The Šidák method was used in case of multiple testing.
An electronic screening of the literature (MEDLINE/Pubmed, Cochrane Library and Embase) and a supplementary manual search were performed. Animal investigations with a minimum sample size of 3 units evaluating implants made of zirconia (ZrO) or its composites (ZrO>50vol.%) were included.
The search provided 4577 articles, and finally 54 investigations were included and analyzed. Fifty-two studies included implants made from zirconia, 4 zirconia composite implants and 37 titanium implants. In total, 3435 implants were installed in 954 animals.
No significant influence of the evaluated bulk materials on the outcomes of interest could be detected. When comparing different animal models, significant differences for the evaluated variables could be found. These results might be of interest for the design of further animal investigations.
确定临床前研究中氧化锆（ZrO）牙科种植体的骨整合率。
考虑到骨与种植体接触（BIC）、去除扭矩分析（RTQ）和推入试验，提取了骨整合率的数据。使用多级多变量混合效应线性回归模型进行荟萃分析。在进行多次测试的情况下，使用 Šidák 方法。
通过电子筛选文献（MEDLINE/Pubmed、Cochrane 图书馆和 Embase）和补充手动搜索进行了筛选。纳入了最小样本量为 3 个单位的评估氧化锆（ZrO）或其复合材料（ZrO>50vol.%）制成的种植体的动物研究。
搜索提供了 4577 篇文章，最终纳入并分析了 54 项研究。52 项研究包括氧化锆制成的植入物，4 项氧化锆复合材料植入物和 37 项钛植入物。总共在 954 只动物中植入了 3435 个植入物。
未发现评估的块状材料对关注结果有显著影响。当比较不同的动物模型时，可以发现评估变量的显著差异。这些结果可能对进一步的动物研究设计感兴趣。
