Petrova Deva, Smickovska Snezana, Lazarevska Emilija
Clinical Hospital Acibademsistina, Skopje, Republic of Macedonia.
University Clinic of Radiotherapy and Oncology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
Open Access Maced J Med Sci. 2017 Sep 17;5(6):736-739. doi: 10.3889/oamjms.2017.161. eCollection 2017 Oct 15.
The treatment of breast cancer involves a multidisciplinary approach in which radiotherapy plays a key role.
The conformity index and the homogeneity index are two analysis tools of a treatment plan using conformal radiotherapy. The purpose of this article is an analysis of these two parameters in the assessment of the treatment plans in 58 patients undergoing postoperative radiotherapy of the whole breast.
All 58 patients participating in the study had a conservatively treated early-stage breast cancer. The treatment was performed using a standard regimen of fractionation in 25 fractions up to a total dose of 50 Gy. Dose-volume histograms were generated for both plans with and without segmental fields.
Pair samples t-test was used. The technique with segmental fields allowed us more homogeneity distribution when compared to standard two tangential field techniques. The HI values were 1.08 ± 0.01 and 1.09 ± 0.01 for segment and technique with two tangential fields (p < 0.001). The DHI values were 0.92 ± 0.02 and 0.901 ± 0.01 for segment and technique with two tangential fields (p < 0.001). The CI values were 1.38 ± 0.02 and 1.43 ± 0.3 for segment and technique with two tangential fields (p = 0.0018).
The results showed that the conformity and the homogeneity index are important tools in the analysis of the treatment plans during radiation therapy in patients with early-stage breast cancer. Adding segment fields in the administration of radiotherapy in patients with conservatively treated breast cancer can lead to improved dosage homogeneity and conformity.
乳腺癌的治疗采用多学科方法，其中放射治疗起着关键作用。
适形指数和均匀性指数是适形放射治疗计划的两种分析工具。本文旨在分析这两个参数在58例全乳术后放疗患者治疗计划评估中的情况。
参与研究的58例患者均为早期乳腺癌且接受了保乳治疗。采用标准分割方案，分25次照射，总剂量达50 Gy。分别生成有和无楔形野的两种计划的剂量体积直方图。
采用配对样本t检验。与标准的两切线野技术相比，楔形野技术使剂量分布更均匀。楔形野技术和两切线野技术的HI值分别为1.08±0.01和1.09±0.01（p<0.001）。楔形野技术和两切线野技术的DHI值分别为0.92±0.02和0.901±0.01（p<0.001）。楔形野技术和两切线野技术的CI值分别为1.38±0.02和1.43±0.3（p = 0.0018）。
结果表明，适形指数和均匀性指数是早期乳腺癌患者放射治疗中治疗计划分析的重要工具。在保乳治疗的乳腺癌患者放疗中增加楔形野可提高剂量均匀性和适形性。
