Kinebuchi Miyuki, Matsuura Akihiro
Department of Molecular Pathology Graduate School of Medicine Fujita Health University Toyoake Aichi Japan.
Acute Med Surg. 2014 Dec 15;2(3):169-175. doi: 10.1002/ams2.100. eCollection 2015 Jul.
We aimed to show the status of intracellular elements in sympathetic preganglionic neurons in an autopsy case of a 55-year-old woman with severe sepsis and cardiac dysfunction with anorexia nervosa.
Our methods include a case report and pathological examinations of autopsied tissues using synchrotron-generated microbeam X-ray fluorescence analysis.
A case report of severe sepsis and myocardial dysfunction. The patient had sudden short cardiac arrest without arrhythmia and sequelae, and echocardiogram showed negative inotropic change. The X-ray fluorescence analysis of autopsied tissues indicated an unusually high concentration of cytosolic calcium in sympathetic preganglionic neurons. However, there were no significant pathological findings of damage in the heart or the cardiovascular autonomic nuclei in the central nervous system.
The data indicate that dysfunction of the sympathetic preganglionic neurons exists in a patient of severe sepsis and cardiac dysfunction with anorexia nervosa.
我们旨在展示一名患有严重脓毒症、心脏功能障碍且伴有神经性厌食症的55岁女性尸检病例中交感神经节前神经元内细胞成分的状况。
我们的方法包括病例报告以及使用同步加速器产生的微束X射线荧光分析对尸检组织进行病理检查。
严重脓毒症和心肌功能障碍的病例报告。该患者突发短暂心脏骤停，无心律失常及后遗症，超声心动图显示心肌收缩力呈负性改变。尸检组织的X射线荧光分析表明，交感神经节前神经元的胞质钙浓度异常高。然而，心脏或中枢神经系统中心血管自主神经核并无明显的损伤病理表现。
数据表明，在患有严重脓毒症、心脏功能障碍且伴有神经性厌食症的患者中存在交感神经节前神经元功能障碍。
