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非医院环境中产生金属β-内酰胺酶的感染。

Metallo-β-lactamase-producing infection in a non-hospital environment.

作者信息

Okazaki Rumi, Hagiwara Shuichi, Kimura Takao, Tokue Yutaka, Kambe Masahiko, Murata Masato, Aoki Makoto, Kaneko Minoru, Oshima Kiyohiro, Murakami Masami

机构信息

Clinical Laboratory Center Gunma University Hospital Maebashi Gunma Japan.

Department of Emergency Medicine Gunma University Graduate School of Medicine Maebashi Gunma Japan.

出版信息

Acute Med Surg. 2015 Apr 27;3(1):32-35. doi: 10.1002/ams2.120. eCollection 2016 Jan.

DOI:10.1002/ams2.120
PMID:29123745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5667230/
Abstract

CASE

A 92-year-old female resident at a nursing home was transported to the emergency department unconscious, hypotensive, and febrile. Chest X-rays and computed tomography revealed a permeation shadow in the right lung. The patient was diagnosed with sepsis due to pneumonia. At the time of admission, she had not received antibiotics or treatment using medical devices over the past 6 months. Two sets of samples were taken for blood and sputum cultures, and was isolated from all cultures. The strain was identified as metallo-β-lactamase-producing , and the patient was successfully treated with tazobactam-piperacillin. This case indicates that metallo-β-lactamase-producing infection occurred in a non-hospital environment.

OUTCOME

After tazobactam-piperacillin treatment, the patient was transferred to another hospital.

CONCLUSION

Emergency physicians should be aware of multidrug-resistant bacterial infection even in a non-hospital setting.

摘要

病例

一名92岁的养老院女性居民被送往急诊科,当时处于昏迷、低血压和发热状态。胸部X光片和计算机断层扫描显示右肺有浸润阴影。该患者被诊断为肺炎导致的败血症。入院时,她在过去6个月内未接受过抗生素治疗或使用过医疗设备。采集了两组血液和痰液样本进行培养,所有培养物中均分离出[具体细菌名称未给出]。该菌株被鉴定为产金属β-内酰胺酶的[具体细菌名称未给出],患者使用他唑巴坦-哌拉西林成功治疗。该病例表明产金属β-内酰胺酶的[具体细菌名称未给出]感染发生在非医院环境中。

结果

经过他唑巴坦-哌拉西林治疗后,患者被转至另一家医院。

结论

急诊医生即使在非医院环境中也应意识到多重耐药细菌感染。

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本文引用的文献

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Community spread of extended-spectrum β-lactamase-producing Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis: a long-term study in Japan.产超广谱β-内酰胺酶大肠埃希菌、肺炎克雷伯菌和奇异变形杆菌的社区传播:日本的一项长期研究。
J Med Microbiol. 2013 Jul;62(Pt 7):1038-1043. doi: 10.1099/jmm.0.059279-0. Epub 2013 Mar 28.
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Epidemiology of Escherichia coli, Klebsiella species, and Proteus mirabilis strains producing extended-spectrum β-lactamases from clinical samples in the Kinki Region of Japan.日本近畿地区临床样本中产超广谱β-内酰胺酶的大肠杆菌、克雷伯菌属和奇异变形杆菌的流行病学研究。
Am J Clin Pathol. 2012 Apr;137(4):620-6. doi: 10.1309/AJCP48PDVKWQOXEZ.
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Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae.耐多药肠杆菌科中令人震惊的β-内酰胺酶介导的耐药性。
Curr Opin Microbiol. 2010 Oct;13(5):558-64. doi: 10.1016/j.mib.2010.09.006. Epub 2010 Oct 1.
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Community-onset bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli: risk factors and prognosis.产超广谱β-内酰胺酶大肠埃希菌引起的社区获得性菌血症:危险因素和预后。
Clin Infect Dis. 2010 Jan 1;50(1):40-8. doi: 10.1086/649537.
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Nosocomial outbreak of genetically related IMP-1 beta-lactamase-producing Klebsiella pneumoniae in a general hospital in Japan.日本一家综合医院内产基因相关IMP-1β-内酰胺酶的肺炎克雷伯菌的医院感染暴发。
Int J Antimicrob Agents. 2007 Mar;29(3):306-10. doi: 10.1016/j.ijantimicag.2006.10.011. Epub 2007 Feb 2.
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