备解素因子B多态性。Bf O等位基因存在的一个指征。

Properdin factor B-polymorphism. An indication for the existence of a Bf O-allele.

作者信息

Weidinger S, Schwarzfischer F, Cleve H

出版信息

Z Rechtsmed. 1979 Aug;83(3):259-64. doi: 10.1007/BF02333329.

Abstract

The polymorphism of the properdin factor B (Bf, C3-proactivator, GBG = glycin-rich-beta-glycoprotein) has been investigated by high voltage agarose gel immunofixation electrophoresis in 1115 unrelated persons from Southern Germany. Seven phenotypes were observed; the allele frequencies were calculated as BfS = 0.8094, BfF = 0.1790, BfSI = 0.0094, BfFI = 0.0022. A study of 94 parents with 98 children and 420 mother-child combinations showed no deviation from the assumed autosomal codominant mode of inheritance. In one additional family the findings suggested the existence of a silent allele at the Bf-locus.

摘要

利用高压琼脂糖凝胶免疫固定电泳技术，对来自德国南部的1115名无血缘关系的个体进行了备解素因子B（Bf，C3前活化因子，GBG = 富含甘氨酸的β糖蛋白）多态性的研究。观察到7种表型；计算出的等位基因频率为BfS = 0.8094，BfF = 0.1790，BfSI = 0.0094，BfFI = 0.0022。对94对父母及其98个孩子以及420对母婴组合的研究表明，其遗传方式符合假定的常染色体共显性遗传模式，无偏差。在另外一个家庭中，研究结果提示在Bf基因座存在一个沉默等位基因。