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[古德帕斯丘综合征:一名年轻男性的眼部表现]

[Goodpasture syndrome: ocular manifestation in a young man].

作者信息

Lommatzsch C, Lommatzsch A, Heinz C, Heiligenhaus A

机构信息

Augenzentrum, St. Franziskus Krankenhaus Münster, Hohenzollernring 74, 48145, Münster, Deutschland.

Universitätsaugenklinik der Universität Duisburg-Essen, Essen, Deutschland.

出版信息

Ophthalmologe. 2018 Sep;115(9):761-764. doi: 10.1007/s00347-017-0612-x.

Abstract

Goodpasture syndrome (GS) is a rare organ-specific autoimmune disease that may consist of glomerulonephritis and pulmonary hemorrhage. Only few case reports have been published on ocular symptoms in the context of GS. This is a case report of a 22-year-old male with GS who was referred to our practice because of visual disturbances. The anamnesis revealed pulmonary hemorrhage, acute renal failure and nephrotic syndrome, which was treated by immunosuppressive therapy with additional plasmapheresis. Ophthalmoscopically, bilateral cotton wool spots were found along the vessels and bilateral retinal hemorrhages predominantly at the posterior pole. By intensifying the existing antihypertensive therapy the eyesight showed significant improvement. Although infrequently seen in Goodpasture syndrome it is important to be aware of ocular symptoms as they may be the initial signs of GS.

摘要

肺出血肾炎综合征(GS)是一种罕见的器官特异性自身免疫性疾病,可包括肾小球肾炎和肺出血。关于GS患者眼部症状的病例报告仅有少数发表。本文报告一例22岁患有GS的男性患者,因视力障碍转诊至我院。既往史显示有肺出血、急性肾衰竭和肾病综合征,采用免疫抑制治疗并辅以血浆置换进行治疗。眼底检查发现沿血管双侧有棉絮斑,双侧视网膜出血主要位于后极部。通过强化现有的降压治疗,视力有显著改善。尽管在肺出血肾炎综合征中眼部症状不常见,但认识到这些症状很重要,因为它们可能是GS的首发体征。

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