Katz Tiffany A, Wu Anna H, Stanczyk Frank Z, Wang Renwei, Koh Woon-Puay, Yuan Jian-Min, Oesterreich Steffi, Butler Lesley M
Department of Pharmacology and Chemical Biology, Women's Cancer Research Center, Magee Women's Research Institute, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
Department of Molecular and Cellular Biology, The Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
Cancer Causes Control. 2018 Jan;29(1):51-62. doi: 10.1007/s10552-017-0978-8. Epub 2017 Nov 9.
Mechanistic and observational data together support a role for prolactin in breast cancer development. Determinants of prolactin in Asian populations have not been meaningfully explored, despite the lower risk of breast cancer in Asian populations.
Determinants of plasma prolactin were evaluated in 442 postmenopausal women enrolled in the Singapore Chinese Health Study, a population-based prospective cohort study. At baseline all cohort members completed an in-person interview that elicited information on diet, menstrual and reproductive history, and lifestyle factors. One year after cohort initiation we began collecting blood samples. Quantified were plasma concentrations of prolactin, estrone, estradiol, testosterone, androstenedione, and sex hormone-binding globulin (SHBG). Analysis of covariance method was used for statistical analyses with age at blood draw, time since last meal, and time at blood draw as covariates.
Mean prolactin levels were 25.1% lower with older age at menarche (p value = 0.001), and 27.6% higher with greater years between menarche and menopause (p value = 0.009). Prolactin levels were also positively associated with increased sleep duration (p value = 0.005). The independent determinants of prolactin were years from menarche to menopause, hours of sleep, and the plasma hormones estrone and SHBG (all p values < 0.01).
The role of prolactin in breast cancer development may involve reproductive and lifestyle factors, such as a longer duration of menstrual cycling and sleep patterns.
机制性和观察性数据共同支持催乳素在乳腺癌发展中的作用。尽管亚洲人群患乳腺癌的风险较低，但尚未对亚洲人群中催乳素的决定因素进行有意义的探索。
在新加坡华人健康研究中，对442名绝经后女性血浆催乳素的决定因素进行了评估，该研究是一项基于人群的前瞻性队列研究。在基线时，所有队列成员都完成了一次面对面访谈，收集了饮食、月经和生殖史以及生活方式因素等信息。队列开始一年后，我们开始采集血样。对催乳素、雌酮、雌二醇、睾酮、雄烯二酮和性激素结合球蛋白（SHBG）的血浆浓度进行了定量测定。采用协方差分析方法进行统计分析，将采血时的年龄、距上次进餐时间和采血时间作为协变量。
初潮年龄较大时，平均催乳素水平降低25.1%（p值=0.001），初潮与绝经之间的间隔时间越长，催乳素水平升高27.6%（p值=0.009）。催乳素水平还与睡眠时间增加呈正相关（p值=0.005）。催乳素的独立决定因素是初潮到绝经的年限、睡眠时间以及血浆激素雌酮和SHBG（所有p值<0.01）。
催乳素在乳腺癌发展中的作用可能涉及生殖和生活方式因素，如月经周期持续时间较长和睡眠模式。
