Hirko Kelly A, Spiegelman Donna, Barnett Junaidah B, Cho Eunyoung, Willett Walter C, Hankinson Susan E, Eliassen A Heather
Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Cancer Epidemiol Biomarkers Prev. 2016 May;25(5):791-8. doi: 10.1158/1055-9965.EPI-15-1019. Epub 2016 Mar 15.
Sex hormones are important for breast cancer, but it is unclear whether dietary patterns influence hormone concentrations.
Dietary pattern adherence scores for the alternate Mediterranean diet (aMED), Dietary Approaches to Stop Hypertension (DASH), and Alternative Healthy Eating Index (AHEI) were calculated from semiquantitative food frequency questionnaires administered in 1995 and 1999. Premenopausal plasma concentrations of sex hormones were measured in samples collected in 1996 to 1999. We used generalized linear models to calculate geometric mean hormone concentrations across quartiles of dietary pattern scores among 1,990 women in the Nurses' Health Study II.
We did not observe significant associations between sex hormone concentrations and the DASH pattern and only one suggestive association between follicular estrone concentrations and the aMED pattern [top vs. bottom quartile -4.4%, 95% confidence interval (CI), -10.6% to 2.1%; Ptrend = 0.06]. However, women in the top versus bottom quartile of AHEI score had lower concentrations of follicular (-9.1%; 95% CI, -16.1% to -1.4%; Ptrend = 0.04) and luteal (-7.5%; 95% CI, -13.6% to -0.9%; Ptrend = 0.01) estrone, luteal-free (-9.3%; 95% CI, -16.8% to -1.1%; Ptrend = 0.01) and total (-6.7 %; 95% CI, -14.3% to 1.5%; Ptrend = 0.04) estradiol, follicular estradiol (-14.2%; 95% CI, -24.6% to -2.4%; Ptrend = 0.05), and androstenedione (-7.8%; 95% CI, -15.4% to 0.4%; Ptrend = 0.03).
Diet quality measured by the AHEI is inversely associated with premenopausal estrogen concentrations. Given that we did not observe similar associations with the aMED or DASH patterns, our findings should be interpreted with caution.
Given the role of estrogens in breast cancer etiology, our findings add to the substantial evidence on the benefits of adhering to a healthy diet. Cancer Epidemiol Biomarkers Prev; 25(5); 791-8. ©2016 AACR.
性激素对乳腺癌很重要，但饮食模式是否会影响激素浓度尚不清楚。
根据1995年和1999年进行的半定量食物频率问卷计算交替地中海饮食（aMED）、终止高血压饮食方法（DASH）和替代健康饮食指数（AHEI）的饮食模式依从性得分。在1996年至1999年收集的样本中测量绝经前血浆性激素浓度。我们使用广义线性模型计算护士健康研究II中1990名女性饮食模式得分四分位数区间内的几何平均激素浓度。
我们未观察到性激素浓度与DASH模式之间存在显著关联，仅观察到卵泡期雌酮浓度与aMED模式之间存在一个提示性关联[最高四分位数与最低四分位数相比为-4.4%，95%置信区间（CI）为-10.6%至2.1%；P趋势=0.06]。然而，AHEI得分最高四分位数与最低四分位数的女性，其卵泡期雌酮浓度（-9.1%；95%CI为-16.1%至-1.4%；P趋势=0.04）、黄体期雌酮浓度（-7.5%；95%CI为-13.6%至-0.9%；P趋势=0.01）、黄体期游离雌二醇浓度（-9.3%；95%CI为-16.8%至-1.1%；P趋势=0.01）、总雌二醇浓度（-6.7%；95%CI为-14.3%至1.5%；P趋势=0.04）、卵泡期雌二醇浓度（-14.2%；95%CI为-24.6%至-2.4%；P趋势=0.05）和雄烯二酮浓度（-7.8%；95%CI为-15.4%至0.4%；P趋势=0.03）较低。
用AHEI衡量的饮食质量与绝经前雌激素浓度呈负相关。鉴于我们未观察到与aMED或DASH模式有类似关联，我们的研究结果应谨慎解读。
鉴于雌激素在乳腺癌病因学中的作用，我们的研究结果为坚持健康饮食的益处提供了大量证据。《癌症流行病学、生物标志物与预防》；25(5)；791 - 8。©2016美国癌症研究协会。
