Dave Kaushalkumar, Krishna Venuganti Venkata Vamsi
Current Affiliation: Division of Biopharmaceutics, Office of New Drug Products, Office of Pharmaceutical Quality, Center for Drug Evaluation & Research, Food & Drug Administration, Silver Spring, MD 20993, USA.
Department of Pharmacy, Birla Institute of Technology & Science (BITS) Pilani, Hyderabad Campus, Hyderabad 500078, Telangana, India.
Ther Deliv. 2017 Dec;8(12):1077-1096. doi: 10.4155/tde-2017-0091.
Skin-mediated therapeutic delivery is a potential alternative to traditional drug delivery approaches. However, dermal drug delivery is limited to the molecules with optimal physico-chemical properties. To overcome this barrier for delivering 'nonideal' drug molecules across the skin, different drug carriers and penetration enhancement methods have been investigated. Conventional chemical and physical approaches for dermal drug delivery are limited by their skin irritation potential, complexity of application and poor patient compliance. In recent years, dendritic polymers have shown potential in improving the dermal delivery of various molecules. With minimal skin irritation potential and high drug loading capacity, dendrimers offer multiple advantages for improving delivery of drugs across the skin. The current review aims to provide an overview of dendritic polymers for dermal (topical and transdermal) drug delivery. [Formula: see text].
皮肤介导的治疗性给药是传统药物递送方法的一种潜在替代方案。然而，皮肤给药仅限于具有最佳物理化学性质的分子。为了克服将“非理想”药物分子透过皮肤递送的这一障碍，人们研究了不同的药物载体和渗透增强方法。传统的皮肤给药化学和物理方法受到其潜在的皮肤刺激性、应用复杂性和患者依从性差的限制。近年来，树枝状聚合物在改善各种分子的皮肤递送方面显示出潜力。树枝状聚合物具有最小的皮肤刺激潜力和高载药能力，在改善药物经皮递送方面具有多种优势。本综述旨在概述用于皮肤（局部和透皮）给药的树枝状聚合物。[公式：见正文]
