Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1; The Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1.
Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1; The Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1; Department of Community Health Sciences and O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1.
Mult Scler Relat Disord. 2018 Jan;19:35-39. doi: 10.1016/j.msard.2017.11.003.
The prevalence of anxiety and its association with sociodemographic and clinical factors is not well characterized in those with multiple sclerosis (MS). We aimed to estimate the prevalence and examine associated factors of anxiety in persons with MS.
A cross-sectional analysis was conducted utilizing data from 244 participants from the Neurological Disease and Depression study. Anxiety was assessed using the Hospital Anxiety and Depression Scale (HADS). Descriptive statistics and multiple logistic regression was used to examine anxiety and associated factors.
Nearly 30.0% of participants had anxiety according to the HADS. The most prevalent symptom of anxiety was "worrying thoughts" (26.6%). After adjustment for various confounders, depression (OR: 7.31 95% CI 3.29-16.26) was found to be associated with higher odds of anxiety, while lower odds of anxiety were associated with higher education (OR: 0.51, 95% CI 0.28-0.94). Furthermore, anxiety was strongly associated with decreased quality of life.
Anxiety represents a substantial burden for those with MS and is associated with a variety of adverse outcomes including decreased quality of life. Our results further emphasize the importance of understanding the impact of anxiety in this population.
焦虑在多发性硬化症（MS）患者中的患病率及其与社会人口学和临床因素的关联尚不清楚。我们旨在评估 MS 患者焦虑的患病率并探讨其相关因素。
利用来自神经疾病和抑郁研究的 244 名参与者的数据进行了横断面分析。使用医院焦虑和抑郁量表（HADS）评估焦虑。采用描述性统计和多逻辑回归来检查焦虑及其相关因素。
根据 HADS，近 30.0%的参与者有焦虑。焦虑最常见的症状是“忧虑思想”（26.6%）。调整了各种混杂因素后，发现抑郁（OR：7.31 95%CI 3.29-16.26）与焦虑的几率更高相关，而接受更高教育（OR：0.51，95%CI 0.28-0.94）与焦虑几率更低相关。此外，焦虑与生活质量下降密切相关。
焦虑对 MS 患者来说是一个重大负担，与多种不良后果相关，包括生活质量下降。我们的研究结果进一步强调了在该人群中了解焦虑影响的重要性。
