Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Epilepsia. 2017 Aug;58(8):e107-e110. doi: 10.1111/epi.13817. Epub 2017 Jun 9.
The objectives of this study were to estimate the prevalence of, and factors associated with, anxiety in epilepsy. We conducted a cross-sectional analysis using data from the Neurological Disease and Depression Study. The prevalence of anxiety and associated factors were assessed using descriptive statistics and logistic regression. Of the total sample (n = 250 patients), nearly 40.0% of participants had anxiety according to the Hospital Anxiety and Depression Scale. The most prevalent symptom of anxiety was "worrying thoughts" (35.6%). After adjustment for age and sex, depression (odds ratio [OR] = 8.97, 95% confidence interval [CI] = 4.38-18.40), medication side effects (OR = 1.79, 95% CI = 1.04-3.05), smoking (OR = 4.35, 95% CI = 2.27-8.31), and illicit substance use (OR = 2.42, 95% CI = 1.18-4.96) were significantly associated with higher odds of anxiety, whereas higher education (OR = 0.47, 95% CI = 0.28-0.80) was associated with lower odds of anxiety. Furthermore, participants with anxiety reported more severe epilepsy, debilitating seizures, and overall lower quality of life. Evidence from our study reveals a high prevalence of anxiety in persons with epilepsy and that anxiety is associated with a variety of negative outcomes. These findings further emphasize the need for more studies to understand the impact of anxiety and its relationship with various sociodemographic and clinical factors.
本研究旨在评估癫痫患者焦虑的患病率及其相关因素。我们采用神经疾病和抑郁研究的数据进行了横断面分析。使用描述性统计和逻辑回归评估了焦虑的患病率及其相关因素。在总样本（n=250 名患者）中，近 40.0%的参与者根据医院焦虑和抑郁量表存在焦虑。焦虑最常见的症状是“忧虑思维”（35.6%）。在校正年龄和性别后，抑郁（比值比[OR] = 8.97，95%置信区间[CI] = 4.38-18.40）、药物副作用（OR = 1.79，95%CI = 1.04-3.05）、吸烟（OR = 4.35，95%CI = 2.27-8.31）和非法药物使用（OR = 2.42，95%CI = 1.18-4.96）与更高的焦虑可能性显著相关，而较高的教育程度（OR = 0.47，95%CI = 0.28-0.80）与较低的焦虑可能性相关。此外，焦虑患者报告癫痫更严重、发作更频繁，总体生活质量更低。本研究的证据表明，癫痫患者中焦虑的患病率较高，且焦虑与多种不良结局相关。这些发现进一步强调需要更多研究来了解焦虑的影响及其与各种社会人口学和临床因素的关系。
