基于基因组学的放线菌天然产物发现。
Genomics-Driven Natural Product Discovery in Actinomycetes.
机构信息
Biotechnology Research Center, Southwest University, Chongqing 400716, China; Academy of Agricultural Sciences, Southwest University, Chongqing 400716, China.
出版信息
Trends Biotechnol. 2018 Mar;36(3):238-241. doi: 10.1016/j.tibtech.2017.10.009. Epub 2017 Nov 7.
Abstract
The prevalence of antimicrobial-resistant pathogens has highlighted the urgent need for new drugs. Actinomycetes have been the most prominent sources of natural products for drug discovery and development. Advances in genomics have inspired several emerging strategies to reinvigorate the field of natural product discovery, especially in actinomycete-derived natural products.
摘要
抗微生物药物耐药性病原体的流行凸显了对新药的迫切需求。放线菌一直是药物发现和开发的天然产物的最主要来源。基因组学的进步激发了几种新兴策略，以重振天然产物发现领域，尤其是放线菌来源的天然产物。
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