Lindahl S, Kugelberg J, Okmian L
Acta Anaesthesiol Scand. 1979 Aug;23(4):370-8. doi: 10.1111/j.1399-6576.1979.tb01464.x.
The circulatory response to different ventilatory patterns during artificial ventilation was examined in 17 sternotomized piglets. A constant CO2-tension level was maintained in all investigations by reference to analyses of the end-tidal infra-red CO2 fraction and arterial CO2-tension. The greatest variation in mean values for end-tidal CO2-tension was 0.2 kPa. Total compliance and lung compliance were lower at a ventilator volume/pressure quotient of 20 compared to those at 80 ml/kPa, and at f = 30 compared to f = 11 cycles/min. Higher cardiac output, lower pulmonary vascular resistance and systemic vascular resistance were measured at f = 11 (inspiration 20%) than at f = 30 (inspiration 50%). An increase in inspiration time by about 100% at the lower ventilatory frequency (f = 11) resulted in a significant but uncompensated decrease in cardiac output and stroke volume. These results demonstrate the value of a rapid insufflation in order to give longer expiration time per minute for the benefit of the venous return and cardiac output.
在17只接受胸骨切开术的仔猪中，研究了人工通气期间不同通气模式的循环反应。在所有研究中，通过参考呼气末红外二氧化碳分数和动脉二氧化碳张力分析，维持恒定的二氧化碳张力水平。呼气末二氧化碳张力平均值的最大变化为0.2 kPa。与通气量/压力商为80 ml/kPa时相比，通气量/压力商为20时的总顺应性和肺顺应性更低；与频率f = 11次/分钟相比，频率f = 30时更低。与f = 30（吸气占比50%）时相比，f = 11（吸气占比20%）时测得的心输出量更高，肺血管阻力和体循环血管阻力更低。在较低通气频率（f = 11）下，吸气时间增加约100%，导致心输出量和每搏输出量显著但未得到代偿的下降。这些结果证明了快速充气的价值，以便每分钟有更长的呼气时间，有利于静脉回流和心输出量。
