Huang Siyuan, Holcomb Lee A, Cruz Stephen M, Marinkovic Ksenija
Department of Psychology, San Diego State University, San Diego, CA, USA.
Department of Biology, San Diego State University, San Diego, CA, USA.
Cogn Affect Behav Neurosci. 2018 Feb;18(1):43-57. doi: 10.3758/s13415-017-0551-7.
Heavy episodic drinking, also termed binge drinking, is commonly practiced by young adults. It is accompanied by a range of cognitive, affective, and social problems, but the neural dynamics underlying changes in emotional functions is poorly understood. To investigate the behavioral and brain indices of affective processing as a function of binge drinking, young, healthy participants (23.3 ± 3.3 years) were assigned to two groups (n = 32 each) based on their drinking habits. Binge drinking (BD) participants reported drinking heavily with at least five binge episodes in the last 6 months, whereas light drinkers (LD) reported no more than one binge episode in the last 6 months. Participants provided subjective ratings of emotionally evocative images with negative, positive, erotic, and neutral themes mostly selected from the International Affective Picture System (IAPS). Electroencephalography (EEG) signal was recorded with a 64-channel system and analyzed in theta frequency band (4-7 Hz) with Morlet wavelets. Subjective ratings of the IAPS pictures were equivalent across both groups. However, affective modulation of event-related theta power both during early appraisal and later integrative processing stages was attenuated in BD, particularly those engaging in high-intensity drinking. These findings suggest that binge drinking is associated with altered neurophysiological indices of affective functions that are reflected in lower theta responsivity to emotions. The blunted long-range cortico-cortical and corticolimbic integration is consistent with compromised affective functions in alcohol use disorder. These findings may have implications for diagnostic and intervention strategies in heavy alcohol users.
重度间歇性饮酒，也称为暴饮，在年轻人中很常见。它伴随着一系列认知、情感和社会问题，但情感功能变化背后的神经动力学却知之甚少。为了研究暴饮作为情感加工的行为和大脑指标，根据饮酒习惯将年轻健康的参与者（23.3±3.3岁）分为两组（每组n = 32）。暴饮（BD）组参与者报告在过去6个月中至少有5次暴饮事件，而轻度饮酒者（LD）组报告在过去6个月中不超过1次暴饮事件。参与者对大多选自国际情感图片系统（IAPS）的具有负面、正面、色情和中性主题的情感唤起图像进行主观评分。使用64通道系统记录脑电图（EEG）信号，并使用Morlet小波在θ频段（4-7Hz）进行分析。两组对IAPS图片的主观评分相当。然而，在BD组中，尤其是那些高强度饮酒者，在早期评估和后期整合处理阶段，与事件相关的θ功率的情感调制均减弱。这些发现表明，暴饮与情感功能的神经生理指标改变有关，这表现为对情绪的θ反应性降低。远程皮质-皮质和皮质-边缘系统整合减弱与酒精使用障碍中情感功能受损一致。这些发现可能对重度饮酒者的诊断和干预策略有启示意义。
