Department of Psychology, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182, USA.
Department of Biology, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182, USA.
Biol Psychol. 2019 Sep;146:107732. doi: 10.1016/j.biopsycho.2019.107732. Epub 2019 Jul 22.
Alcohol consumption is often characterized by heavy episodic, or binge drinking, which has been on the rise. The aim of this study was to examine the neural dynamics of inhibitory control in demographically matched groups of young, healthy adults (N = 61) who reported engaging in binge (BD) or light drinking patterns (LD). Electroencephalography signal was recorded during a fast-paced visual Go/NoGo paradigm probing the ability to inhibit prepotent responses. No group differences were found in task performance. BDs showed attenuated event-related theta (4-7 Hz) on inhibition trials compared to LDs, which correlated with binge episodes and alcohol consumption but not with measures of mood or disposition including impulsivity. A greater overall decrease of early beta power (15-25 Hz) in BDs may indicate deficient preparatory "inhibitory brake" before deliberate responding. The results are consistent with deficits in the inhibitory control circuitry and are suggestive of allostatic neuroadaptive changes associated with binge drinking.
饮酒常表现为重度间歇性或 binge 饮酒，且其发生率呈上升趋势。本研究旨在比较报告 binge 饮酒和轻度饮酒模式的年轻健康成年人（N=61）的抑制控制的神经动力学。脑电图信号在快节奏视觉 Go/NoGo 范式中记录，该范式探测抑制优势反应的能力。在任务表现方面，两组之间未发现差异。与轻度饮酒者相比， binge 饮酒者在抑制试验中表现出θ频段（4-7 Hz）的事件相关去同步化减弱，该差异与 binge 饮酒发作和饮酒量相关，但与情绪或性格特征（包括冲动性）无关。 binge 饮酒者的早期β频段（15-25 Hz）功率总体下降更大，这可能表明在故意反应之前准备性“抑制刹车”不足。结果与抑制控制回路的缺陷一致，提示与 binge 饮酒相关的神经适应性变化。
