Jones Blake L, Elwazeer Salma, Taylor Zoe E
Department of Human Development and Family Studies, Purdue University, West Lafayette, Indiana.
Public Health Graduate Program, Purdue University, West Lafayette, Indiana.
Dev Psychobiol. 2018 Jan;60(1):104-110. doi: 10.1002/dev.21577. Epub 2017 Nov 11.
Latino families face increased risk for hypertension. Serum-based uric acid and C-reactive protein have been linked to hypertension. However, a paucity of salivary biomarker data exists in this area for Latino families. Using salivary biomarkers enables less invasive options for biomedical and biosocial research, which is especially important among vulnerable populations facing increased health disparities. This study examined the associations between salivary uric (sUA) acid, salivary C-reactive protein (sCRP), and hypertension among 151 participants (57 children, 57 mothers, 37 fathers) from 57 Midwestern Latino families. Participants self-administered the salivary samples, and blood pressure was measured by researchers. Results showed sUA was associated across family members, and child hypertension was related to parents' hypertension. sCRP was only related to sUA in fathers. Findings highlight the family-level health connections, along with the importance for further investigations using salivary biomarkers with Latinos, and the need for a robust sUA cut-off for hyperuricemia.
拉丁裔家庭患高血压的风险增加。血清尿酸和C反应蛋白与高血压有关。然而，在这一领域，针对拉丁裔家庭的唾液生物标志物数据匮乏。使用唾液生物标志物可为生物医学和生物社会学研究提供侵入性较小的选择，这在面临健康差距加剧的弱势群体中尤为重要。本研究调查了来自57个中西部拉丁裔家庭的151名参与者（57名儿童、57名母亲、37名父亲）的唾液尿酸（sUA）、唾液C反应蛋白（sCRP）与高血压之间的关联。参与者自行采集唾液样本，研究人员测量血压。结果显示，sUA在家庭成员中具有相关性，儿童高血压与父母的高血压有关。sCRP仅在父亲中与sUA相关。研究结果突出了家庭层面的健康联系，以及使用唾液生物标志物对拉丁裔进行进一步研究的重要性，以及确定高尿酸血症的可靠sUA临界值的必要性。
