Division of Public Health, College of Human Medicine, Michigan State University, 200 East 1st Street, Flint, MI, 48502, United States; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, 909 Wilson Road, B636, East Lansing, MI, 48824, United States; Institute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, 4201 SBSG, Irvine, CA, 92697-7085, United States.
Institute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, 4201 SBSG, Irvine, CA, 92697-7085, United States; Department of Psychological Science, School of Social Ecology, University of California Irvine, 4201 SBSG, Irvine, CA, 92697-7085, United States.
Biol Psychol. 2020 May;153:107882. doi: 10.1016/j.biopsycho.2020.107882. Epub 2020 Mar 24.
High uric acid (UA) is associated with hypertension and cardiovascular disease (CVD), both of which occur disproportionately among African Americans. High UA also predicts greater blood pressure reactivity responses to acute social stress. However, whether UA itself shows reactivity in response to stress is unknown. We evaluated salivary uric acid (sUA) and blood pressure reactivity in response to acute social stress. Healthy African Americans (N = 103; 32 % male; M age = 31.36 years), completed the Trier Social Stress Test. sUA and blood pressure measurements were taken before, during and after the stressor task. sUA showed significant reactivity and recovery, especially among older African Americans. Total sUA activation was also associated with systolic and diastolic blood pressure total activation. Findings illuminate that acute stress may be a way in which UA is implicated in hypertension and CVD, suggesting a critical need to explore UA reactivity as a novel parameter of the acute stress response.
高尿酸（UA）与高血压和心血管疾病（CVD）有关，而这两种疾病在非裔美国人中发生的比例不成比例。高尿酸还预测急性社会应激时血压反应性更大。然而，UA 本身是否对压力有反应性尚不清楚。我们评估了唾液尿酸（sUA）和血压对急性社会应激的反应性。健康的非裔美国人（N=103；32%为男性；M 年龄=31.36 岁）完成了特里尔社会应激测试。在应激任务之前、期间和之后采集 sUA 和血压测量值。sUA 表现出明显的反应性和恢复性，尤其是在年龄较大的非裔美国人中。总 sUA 激活也与收缩压和舒张压总激活相关。这些发现表明，急性应激可能是 UA 参与高血压和 CVD 的一种方式，这表明迫切需要探索 UA 反应性作为急性应激反应的一个新参数。
