Department of Psychiatry, Yale University, 389 Whitney Ave., New Haven, CT, 06511, United States.
Division of Public Health, Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, 200 East 1(st) Street, Flint, MI, 48502, United States; Department of Psychology, Wayne State University, 5057 Woodward Ave., Detroit, MI, 48202, United States; Institute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, 4201 SBSG., Irvine, CA, 92697-7085, United States.
Psychoneuroendocrinology. 2019 Mar;101:19-26. doi: 10.1016/j.psyneuen.2018.10.025. Epub 2018 Oct 26.
High levels of uric acid are associated with greater risk of stress-related cardiovascular illnesses that occur disproportionately among African Americans. Whether hyperuricemia affects biological response to acute stress remains largely unknown, suggesting a need to clarify this potential connection. The current study examined how salivary uric acid (sUA) is associated with resting and reactive blood pressure - two robust predictors of hypertension and related cardiovascular disease and disparity. Healthy African Americans (N = 107; 32% male; M age = 31.74 years), completed the Trier Social Stress Test to induce social-evaluative stress. Systolic and diastolic blood pressure readings were recorded before, during, and after the task to assess resting and reactive change in blood pressure. Participants also provided a saliva sample at baseline that was assayed for sUA. At rest, and controlling for age, sUA was modestly associated with higher systolic (r = .201, p = .044), but not diastolic (r = .100, p = .319) blood pressure. In response to the stressor task, and once again controlling for age, sUA was also associated with higher total activation of both systolic (r = .219, p = .025) and diastolic blood pressure (r = .198, p < .044). A subsequent moderation analysis showed that associations between sUA and BP measures were significant for females, but not for males. Findings suggest that uric acid may be implicated in hypertension and cardiovascular health disparities through associations with elevated blood pressure responses to acute social stress, and that low levels of uric acid might be protective, particularly for females.
尿酸水平较高与应激相关心血管疾病的风险增加有关，而这种疾病在非裔美国人中不成比例地发生。高尿酸血症是否会影响对急性应激的生物学反应在很大程度上尚不清楚，这表明需要澄清这种潜在的联系。本研究检查了唾液尿酸（sUA）如何与静息和反应性血压相关——这是高血压和相关心血管疾病及差异的两个强有力的预测指标。健康的非裔美国人（N=107；32%为男性；平均年龄为 31.74 岁）完成了特里尔社会应激测试，以诱发社会评价性应激。在任务前后记录收缩压和舒张压读数，以评估血压的静息和反应性变化。参与者还在基线时提供了唾液样本，用于测定 sUA。在静息状态下，控制年龄因素后，sUA 与较高的收缩压（r=0.201，p=0.044）适度相关，但与舒张压（r=0.100，p=0.319）无关。在应激源任务中，再次控制年龄因素后，sUA 与收缩压（r=0.219，p=0.025）和舒张压（r=0.198，p<0.044）的总激活也相关。随后的调节分析表明，sUA 与 BP 测量之间的关联在女性中显著，但在男性中不显著。研究结果表明，尿酸可能通过与急性社会应激时血压升高反应的关联而与高血压和心血管健康差异有关，而低水平的尿酸可能具有保护作用，特别是对女性而言。
