Vancaillie T G, Eddy C A, Laufe L
Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284.
Fertil Steril. 1989 Feb;51(2):335-8.
In search of an outpatient procedure for female sterilization, the authors performed the following animal study. Two groups of seven rabbits were subjected to laparotomy, hysterotomy, and hysteroscopy. The uterotubal junction (UTJ) was destroyed with bipolar electrical current, and a plug (Aqualloy, Drachten, The Netherlands) was inserted. The plug on the right side contained quinacrine (Q) in group A and platelet extract (PE) in group B. Histologic assessment by serial sections indicated occlusion of the UTJ in all but one case (96% success rate). This one failure is attributed to the technical difficulties associated with hysteroscopy in the rabbit. The authors project that this method may have the potential of becoming an acceptable outpatient procedure for female sterilization in the human.
为寻找一种女性绝育的门诊手术方法，作者进行了如下动物研究。两组各7只兔子接受了剖腹术、子宫切开术和宫腔镜检查。通过双极电流破坏子宫输卵管交界处（UTJ），并插入一个栓子（Aqualloy，荷兰德拉克滕）。右侧栓子在A组中含有奎纳克林（Q），在B组中含有血小板提取物（PE）。通过连续切片进行的组织学评估表明，除1例（成功率96%）外，所有UTJ均发生闭塞。这一失败归因于兔子宫腔镜检查相关的技术困难。作者预计这种方法可能有潜力成为人类可接受的女性绝育门诊手术。
