Seo Tae-Seok, Oh Joo-Hyeong, Yoon Yup, Ryu Kyung-Nam, Lim Joo-Won
Department of Radiology, Gachon Medical School, Gil Medical Center, Inchon, Korea.
J Vasc Interv Radiol. 2002 Apr;13(4):399-404. doi: 10.1016/s1051-0443(07)61743-6.
To test the feasibility of performing transcervical fallopian tube occlusion in a rabbit model with use of unipolar radiofrequency (RF) electrocoagulation.
Under fluoroscopic guidance, transvaginal catheterization of the right or left fallopian tube was first performed with use of a coaxial technique in 20 rabbits. With a metal guide wire protruding from the catheter serving as the active electrode, RF electrocoagulation was performed. The power output was set to 200 W and the current was applied for 20 seconds. The fallopian tube on the contralateral side and the uterus were used as controls. Rabbits were randomly designated to be killed either 2 days (group I, n = 10) or 30 days (group II, n = 10) after the procedure, and tubal patency and histologic changes were evaluated.
In group I, significant necrosis of the endosalpinx caused by RF electrocoagulation was found in all 10 rabbits. In group II, the occluded fallopian tube showed fibrosis of the wall in all 10 rabbits, but there was no tissue damage to adjacent organs. Histologic findings in the contralateral fallopian tubes were normal in all 20 rabbits.
Transcatheter RF electrocoagulation proved to be a safe nonsurgical alternative for occlusion of the fallopian tubes in rabbits.
通过使用单极射频（RF）电凝技术，在兔模型中测试经宫颈输卵管闭塞术的可行性。
在透视引导下，首先采用同轴技术对20只兔的右侧或左侧输卵管进行经阴道插管。以从导管伸出的金属导丝作为活性电极，进行RF电凝。功率输出设定为200W，电流施加20秒。将对侧输卵管和子宫用作对照。术后随机指定兔子在术后2天（I组，n = 10）或30天（II组，n = 10）处死，并评估输卵管通畅情况和组织学变化。
I组中，所有10只兔均发现由RF电凝引起的输卵管内膜显著坏死。II组中，所有10只兔的闭塞输卵管均显示管壁纤维化，但对相邻器官无组织损伤。所有20只兔对侧输卵管的组织学检查结果均正常。
经导管RF电凝被证明是兔输卵管闭塞的一种安全的非手术替代方法。
