Schmitz-Rode T, Ross P L, Timmermans H, Thurmond A S, Günther R W, Rösch J
Department of Diagnostic Radiology, University of Technology, Aachen, Germany.
J Vasc Interv Radiol. 1994 Nov-Dec;5(6):905-10. doi: 10.1016/s1051-0443(94)71635-3.
A nonsurgical method of female sterilization was investigated in rabbits.
A self-expanding microspindle (length 9-18 mm, diameter 1.5-2.0 mm) made from tubular metal mesh was implanted in a single fallopian tube of 12 rabbits via catheterization of a single uterus. The contralateral fallopian tube and uterus served as controls. Each rabbit was scheduled to undergo three cycles of breeding. Before delivery, absence of pregnancy on the side with the microspindle was verified with hysterography.
Eight rabbits completed three cycles of breeding and pregnancy. Two rabbits had one pregnancy. Two rabbits did not conceive. Spindles were placed correctly in 11 rabbits. Successful contraception was achieved in nine rabbits, who had 25 gestations on the nonspindle side and no gestation on the spindle side. One rabbit, which received the shortest spindle, was bilaterally pregnant, indicating a failure of contraception on the spindle side. No spindles dislocated. Histologic study showed all spindles firmly embedded in the tubal wall without signs of inflammation.
Microspindles of a certain minimum length have potential as a transcervically implantable, permanent intratubal contraceptive device.
在兔身上研究一种女性绝育的非手术方法。
将由管状金属网制成的自膨胀微纺锤体（长度9 - 18毫米，直径1.5 - 2.0毫米）通过单子宫插管植入12只兔的单侧输卵管。对侧输卵管和子宫作为对照。每只兔计划进行三个繁殖周期。分娩前，通过子宫输卵管造影术确认微纺锤体侧未怀孕。
8只兔完成了三个繁殖周期并怀孕。2只兔有一次怀孕。2只兔未受孕。11只兔的纺锤体放置正确。9只兔成功避孕，其非纺锤体侧有25次妊娠，纺锤体侧无妊娠。接受最短纺锤体的1只兔双侧怀孕，表明纺锤体侧避孕失败。没有纺锤体移位。组织学研究显示所有纺锤体牢固地嵌入输卵管壁，无炎症迹象。
一定最小长度的微纺锤体有潜力作为经宫颈可植入的永久性输卵管内避孕装置。
