行为性抑郁与成年雌性食蟹猴（Macaca fascicularis）迷走神经介导的心率变异性增加有关。
Behavioral depression is associated with increased vagally mediated heart rate variability in adult female cynomolgus monkeys (Macaca fascicularis).
机构信息
Clinic for Psychosomatic Medicine and Psychotherapy, University Hospital Ulm, Ulm, Germany.
Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, Heidelberg University, Heidelberg, Germany; Department of Psychology, The Ohio State University, Columbus, OH, USA; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
出版信息
Int J Psychophysiol. 2018 Sep;131:139-143. doi: 10.1016/j.ijpsycho.2017.11.004. Epub 2017 Nov 8.
INTRODUCTION
Depressive symptoms (DS) in humans are associated with decreased resting state vagal activity, but sex seems to moderate this association. Recently, in human females DS have been associated with greater or similar cardiac vagal activity compared to men in both, clinical and non-clinical samples. A previously validated animal model of behavioral depression was used in the present study to investigate the association of DS and cardiac vagal activity in non-human primates.
METHODS
The root mean square of successive differences between adjacent heart beats (RMSSD) was used as an indicator of vagally-mediated heart rate variability in 24h heart rate recordings collected via telemetry in 42 adult female cynomolgus monkeys (Macaca fascicularis). Hierarchical regression models were used to estimate differences in RMSSD comparing monkeys with and without DS. To capture circadian variation patterns of RMSSD, additional quadratic, cubic and quartic terms of hour were added.
RESULTS
Monkeys showing behavioral DS had higher overall 24-h RMSSD. The interaction term of daytime with DS and polynomials of hour contributed significantly to the variance across models.
CONCLUSIONS
This is the first study investigating the association of DS and 24h cardiac vagal control in female non-human primates. Results replicate existing human studies showing higher cardiac vagal control in behavioral depressed vs. non-depressed female monkeys.
简介
人类的抑郁症状（DS）与静息状态下迷走神经活动减少有关，但性别似乎会调节这种关联。最近，在临床和非临床样本中，与男性相比，女性的 DS 与更大或相似的心脏迷走神经活动有关。本研究使用了一种经过验证的行为抑郁动物模型，来研究非人类灵长类动物中 DS 与心脏迷走神经活动的关联。
方法
通过遥测技术在 42 只成年雌性食蟹猴（Macaca fascicularis）中收集 24 小时心率记录，使用相邻心跳之间的均方根差（RMSSD）作为迷走神经介导的心率变异性的指标。使用分层回归模型来比较有和无 DS 的猴子之间 RMSSD 的差异。为了捕捉 RMSSD 的昼夜变化模式，还添加了小时的二次、三次和四次项。
结果
表现出行为 DS 的猴子全天的 RMSSD 整体更高。DS 与白天的交互项和小时的多项式对模型的差异有显著贡献。
结论
这是第一项研究 DS 与女性非人类灵长类动物 24 小时心脏迷走神经控制之间关联的研究。结果复制了现有的人类研究，表明行为抑郁的雌性猴子的心脏迷走神经控制更高。
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