Material Research Laboratory, Department of Chemistry, National Institute of Technology, Calicut 673601, Kerala, India.
Material Research Laboratory, Department of Chemistry, National Institute of Technology, Calicut 673601, Kerala, India.
Int J Biol Macromol. 2018 Mar;108:1261-1272. doi: 10.1016/j.ijbiomac.2017.11.035. Epub 2017 Nov 8.
Nanochitosan (NC) enriched Poly (ε-caprolactone) (PCL) nanofibrous membranes were fabricated for controlled curcumin delivery and wound dressing. A significant increase in hydrophilicity, PBS sorption, and vapour transmission were observed by incorporation of NC in PCL. Hemolysis assay, blood clot kinetics and platelet adhesion studies on PCL/NC membranes confirmed the hemocompatibility of the scaffold. NC also imparts appropriate antibacterial activity and biocompatibility promising for a wound dressing material. 15% NC (PCL/15NC) loaded membrane exhibits excellent bioavailability and sustained release behaviour of curcumin at different pH of 7.4, 5.8 and 1.2 with pH sensitive nature. Thus, it can be concluded that PCL/15NC nanofibrous membrane is a promising material for wound dressings and transdermal patches with tunable drug releasing properties with pH stimulus.
纳米壳聚糖（NC）增强聚己内酯（PCL）纳米纤维膜被制备用于控制姜黄素的递送和伤口敷料。通过在 PCL 中加入 NC，观察到亲水性、PBS 吸附和蒸汽传输显著增加。溶血试验、血小板黏附试验和血液凝固动力学研究证实了支架的血液相容性。NC 还具有适当的抗菌活性和生物相容性，有望成为一种伤口敷料材料。负载 15% NC（PCL/15NC）的膜在不同 pH 值（7.4、5.8 和 1.2）下具有良好的生物利用度和姜黄素的持续释放行为，表现出 pH 敏感性。因此，可以得出结论，PCL/15NC 纳米纤维膜是一种有前途的用于伤口敷料和经皮贴片的材料，具有 pH 刺激的可调药物释放特性。
