Ding Xiaotong, Tang Qinghan, Xu Zeyu, Xu Ye, Zhang Hao, Zheng Dongfeng, Wang Shuqin, Tan Qian, Maitz Joanneke, Maitz Peter K, Yin Shaoping, Wang Yiwei, Chen Jun
School of Pharmacy, Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and Application, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China.
Department of Burns and Plastic Surgery, The affiliated Drum Tow Hospital of Nanjing University of Chinese Medicine, Nanjing 210008, People's Republic of China.
Burns Trauma. 2022 May 21;10:tkac014. doi: 10.1093/burnst/tkac014. eCollection 2022.
Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and mortality. The underlying mechanism of infections has been widely investigated by scientist, while standard wound management is routinely been used in general practice. However, strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization, delayed healing and drug resistance. In the present review, we summarize the common microorganisms found in acute and chronic wound infections and discuss the challenges from the aspects of clinical diagnosis, non-surgical methods and surgical methods. Moreover, we highlight emerging innovations in the development of antimicrobial peptides, phages, controlled drug delivery, wound dressing materials and herbal medicine, and find that sensitive diagnostics, combined treatment and skin microbiome regulation could be future directions in the treatment of wound infection.
急慢性伤口感染已成为全球主要的医疗负担，导致极高的发病率和死亡率。科学家们已对感染的潜在机制进行了广泛研究，而标准伤口处理方法在常规医疗实践中也经常使用。然而，由于生物膜定植、愈合延迟和耐药性的出现，伤口感染的诊断和治疗策略仍然是一个巨大的挑战。在本综述中，我们总结了急慢性伤口感染中常见的微生物，并从临床诊断、非手术方法和手术方法等方面讨论了挑战。此外，我们强调了抗菌肽、噬菌体、控释给药、伤口敷料材料和草药开发方面的新兴创新，并发现灵敏诊断、联合治疗和皮肤微生物群调节可能是未来伤口感染治疗的方向。
