Agić Danijela, Čabarkapa Velibor, Milošević Ivana, Perčić Ivanka, Farra Amir El, Nikolić Stanislava, Sekulić Borivoj, Vlaisavljević Nada, Savić Aleksandar, Urošević Ivana, Popović Stevan L
Clinic for Hematology, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Department of Internal Medicine, Faculty of Medicine, University of Novi Sad, Hajduk Veljka 3, Novi Sad, 21000 Serbia.
Indian J Hematol Blood Transfus. 2024 Apr;40(2):213-219. doi: 10.1007/s12288-023-01695-6. Epub 2023 Sep 17.
Growth and differentiation factor-15 (GDF-15) correlates with worse outcome of many tumours and any cause mortality. Data about its role in lymphoproliferative neoplasms (LPN) are scarce. Our research aimed to reveal the correlation between GDF-15 and standard laboratory parameters of LPN activity, and to get insight into the possible value of this cytokine assessment in lymphoma patients. Prospective research included 40 patients treated for aggressive or indolent LPN, and 31 with indolent LPN on "watch and wait" regimen. Analyses were performed before and after treatment in treated patients and on two separate occasions in the "watch and wait" group. ELISA technique with R&D assays according to the manufacturer manual, from stored sera at - 70 °C was used for GDF-15 level measurement. Statistical analyses were performed by IBM SPSS Statistics 22 using descriptive and inferential statistics. As appropriate, differences between groups were assessed by two tailed -test, Mann-Whitney or x test. Spearman Rank Order Correlation was done to correlate GDF-15 with standard laboratory markers of disease activity. All tests are two-tailed with significance level < 0. 05. GDF-15 ( = 0.028) and fibrinogen ( = 0.001) concentrations increased after treatment in indolent lymphoma patients while β2 microglobulin decreased ( < 0.001). GDF-15 positively correlated with β2microglobulin before ( < 0.001) and after ( = 0.031) therapy. There were no differences in any of the aforementioned parameters in the "watch and wait" group during observation. A positive correlation between GDF-15 and β2 microglobulin in patients with indolent LPN who need treatment suggests potential value in risk assessment.
The online version contains supplementary material available at 10.1007/s12288-023-01695-6.
生长分化因子-15（GDF-15）与许多肿瘤的不良预后及任何原因导致的死亡率相关。关于其在淋巴增殖性肿瘤（LPN）中的作用的数据很少。我们的研究旨在揭示GDF-15与LPN活性的标准实验室参数之间的相关性，并深入了解这种细胞因子评估在淋巴瘤患者中的潜在价值。前瞻性研究包括40例接受侵袭性或惰性LPN治疗的患者，以及31例接受“观察等待”方案的惰性LPN患者。对接受治疗的患者在治疗前后进行分析，对“观察等待”组在两个不同时间点进行分析。使用根据制造商手册采用R&D检测方法的ELISA技术，从-70°C储存的血清中测量GDF-15水平。使用IBM SPSS Statistics 22进行统计分析，采用描述性和推断性统计方法。适当时，通过双侧t检验、Mann-Whitney检验或x检验评估组间差异。进行Spearman等级相关分析以将GDF-15与疾病活动的标准实验室标志物相关联。所有检验均为双侧检验，显著性水平<0.05。惰性淋巴瘤患者治疗后GDF-15（=0.028）和纤维蛋白原（=0.001）浓度升高，而β2微球蛋白降低（<0.001）。治疗前（<0.001）和治疗后（=0.031）GDF-15与β2微球蛋白呈正相关。“观察等待”组在观察期间上述任何参数均无差异。需要治疗的惰性LPN患者中GDF-15与β2微球蛋白之间的正相关表明其在风险评估中的潜在价值。
在线版本包含可在10.1007/s12288-02***-01695-6获取的补充材料。
