Department of Otolaryngology-Head and Neck Surgery, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Republic of Korea.
Biomed Res Int. 2017;2017:3098230. doi: 10.1155/2017/3098230. Epub 2017 Oct 10.
Nanoparticles are promising therapeutic options for inner ear disease. In this report, we review animal studies in the otologic field using nanoparticles over the past 5 years. Many studies have used nanoparticles to deliver drugs, genes, and growth factors, and functional and morphological changes have been observed. The constituents of nanoparticles are also diversifying into various biocompatible materials, including poly(lactic-co-glycolic acid) (PLGA). The safe and effective delivery of drugs or genes in the inner ear will be a breakthrough for the treatment of inner ear diseases, including age-related hearing loss.
纳米颗粒是内耳疾病有前途的治疗选择。在本报告中，我们回顾了过去 5 年中在耳科学领域使用纳米颗粒的动物研究。许多研究已经使用纳米颗粒来递送药物、基因和生长因子，并观察到了功能和形态的变化。纳米颗粒的组成也多样化为各种生物相容性材料，包括聚（乳酸-共-乙醇酸）（PLGA）。在治疗内耳疾病（包括年龄相关性听力损失）方面，药物或基因在内耳中的安全有效传递将是一个突破。
