Hasselmo Michael E, Hinman James R, Dannenberg Holger, Stern Chantal E
Center for Systems Neuroscience, Boston University, 610 Commonwealth Ave., Boston, MA 02215.
Curr Opin Behav Sci. 2017 Oct;17:27-33. doi: 10.1016/j.cobeha.2017.05.024. Epub 2017 Jun 15.
Episodic memory involves coding of the spatial location and time of individual events. Coding of space and time is also relevant to working memory, spatial navigation, and the disambiguation of overlapping memory representations. Neurophysiological data demonstrate that neuronal activity codes the current, past and future location of an animal as well as temporal intervals within a task. Models have addressed how neural coding of space and time for memory function could arise, with both dimensions coded by the same neurons. Neural coding could depend upon network oscillatory and attractor dynamics as well as modulation of neuronal intrinsic properties. These models are relevant to the coding of space and time involving structures including the hippocampus, entorhinal cortex, retrosplenial cortex, striatum and parahippocampal gyrus, which have been implicated in both animal and human studies.
情景记忆涉及对单个事件的空间位置和时间进行编码。空间和时间的编码也与工作记忆、空间导航以及重叠记忆表征的消歧相关。神经生理学数据表明,神经元活动对动物当前、过去和未来的位置以及任务中的时间间隔进行编码。模型已经探讨了用于记忆功能的空间和时间的神经编码是如何产生的,这两个维度都由相同的神经元编码。神经编码可能取决于网络振荡和吸引子动力学以及神经元内在特性的调节。这些模型与涉及海马体、内嗅皮质、 retrosplenial皮质、纹状体和海马旁回等结构的空间和时间编码相关,这些结构在动物和人类研究中都有涉及。